Next Article in Journal
The Application of an Iterative Structure to the Delay-and-Sum and the Delay-Multiply-and-Sum Beamformers in Breast Microwave Imaging
Previous Article in Journal
COVID-19 Diagnostics, Tools, and Prevention
Previous Article in Special Issue
Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine
Open AccessInteresting Images

Brain Metastases Unresponsive to Immunotherapy Detected by 18F-FDG-PET/CT in a Patient with Melanoma

Institute of Biostructures and Bioimages, National Research Council, Via Tommaso De Amicis 95, 80145 Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 410;
Received: 28 May 2020 / Revised: 10 June 2020 / Accepted: 15 June 2020 / Published: 17 June 2020
(This article belongs to the Collection Interesting Images)
Recently, newer therapies such as immunotherapy have been increasingly used in the treatment of several tumors, including advanced melanoma. In particular, several studies showed that the combination of ipilimumab, an anti-Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) monoclonal antibody and nivolumab, an anti-Programmed Death 1 (PD-1) monoclonal antibody, leads to improved survival in patients with metastatic melanoma. Despite that, immunotherapeutic agents may not reach therapeutic concentration in the brain due to the blood–brain barrier. We report the case of a 50-year-old man with advanced melanoma who underwent whole-body 18F-FDG-PET/CT before and after treatment with immunotherapy showing resistant brain metastases confirmed by subsequent MRI of the brain. Moreover, 18F-FDG-PET/CT was able to detect an immune-related adverse event such as enterocolitis that contributed to the worsening of patient conditions. This case shows how a whole-body methodology such as 18F-FDG-PET/CT can be useful in identifying melanoma cancer patients unresponsive to immunotherapy that may benefit from traditional palliative therapy in the effort to improve their quality of life. View Full-Text
Keywords: 18F-FDG-PET/CT; melanoma; immunotherapy; brain metastases 18F-FDG-PET/CT; melanoma; immunotherapy; brain metastases
Show Figures

Figure 1

MDPI and ACS Style

Fonti, R.; Pellegrino, S.; Mainolfi, C.G.; Matano, E.; Del Vecchio, S. Brain Metastases Unresponsive to Immunotherapy Detected by 18F-FDG-PET/CT in a Patient with Melanoma. Diagnostics 2020, 10, 410.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop