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Open AccessReview

Shedding Light on Bladder Cancer Diagnosis in Urine

1
School of Engineering, UniSA STEM, University of South Australia, Mawson Lakes, South Australia, SA 5095, Australia
2
Department of Renal Medicine, Flinders Medical Centre, Bedford Park, South Australia, SA 5042, Australia
3
College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, SA 5042, Australia
4
Future Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes, South Australia, SA 5095, Australia
*
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 383; https://doi.org/10.3390/diagnostics10060383
Received: 27 May 2020 / Revised: 6 June 2020 / Accepted: 6 June 2020 / Published: 8 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Blue light cystoscopy (BLC) is the most recent clinical approach in the detection and diagnosis of bladder cancer, a common type of cancer with a high rate of recurrence. Representing a significant advance over previous approaches, this photodynamic diagnostic technique uses a photosensitiser prodrug as an adjunct to white light cystoscopy to enhance the in vivo detection of malignant tissues in the bladder based on their distinctive fluorescence. Whilst it does improve detection rates, BLC remains an invasive and costly procedure. Meanwhile, a variety of noninvasive urine detection methods and related microdevices have been developed, none of which have yet entered routine clinical use due to unsatisfactory sensitivity. Following a brief description of the current approaches and their limitations, we provide here a systematic review of a newer niche research aiming to develop a noninvasive adaptation of photodynamic diagnosis. The research to date surrounding the ex situ use of photosensitiser prodrugs for urinary diagnosis of bladder cancer is also discussed. View Full-Text
Keywords: bladder cancer; urine; noninvasive; 5-ALA; urinary biomarkers; photodynamic diagnosis bladder cancer; urine; noninvasive; 5-ALA; urinary biomarkers; photodynamic diagnosis
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MDPI and ACS Style

Chan, K.M.; Gleadle, J.; Li, J.; Vasilev, K.; MacGregor, M. Shedding Light on Bladder Cancer Diagnosis in Urine. Diagnostics 2020, 10, 383.

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