Table of Contents
Genes, Volume 10, Issue 12 (December 2019) – 107 articles
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Cover Story (view full-size image) Acute myeloid leukemia (AML) clinical settings cannot do without molecular testing to confirm or [...] Read more. Acute myeloid leukemia (AML) clinical settings cannot do without molecular testing to confirm or rule out predictive biomarkers for prognostic stratification, in order to initiate or withhold targeted therapy. In this context, we present a nanopore-based assay for rapid (24 hours) sequencing of six genes (NPM1, FLT3, CEBPA, TP53, IDH1, and IDH2) that are recurrently mutated in AML. Nanopore ability to generate long reads allows a more accurate detection of longer FLT3 internal tandem duplications and phasing double CEBPA mutations. The workflow proposed can potentially enable all basic molecular biology laboratories to perform detailed targeted gene sequencing analysis in AML patients, in order to define the prognosis and the treatment. View this paper.