Special Issue "Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise"
Deadline for manuscript submissions: closed (31 July 2019).
A printed edition of this Special Issue is available here.
Interests: brain cells; blood-brain barrier; RNA-binding proteins; extracellular vesicles; histone variants
From an evolutionary perspective, our species has relied on physical activity for most of its history (and still does) to survive and has had to escape from predators, to scavenge for food, and to use its physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning, and consequently, our entire body has been programmed to be active physically and not to have a sedentary life.
However, only recently have we started to experience the consequences of the profound modifications that technology, together with highly energetic food diets, have brought into our daily lives. Thus, a lot of initiatives aim to reverse this situation and promote physical activity as a keystone for our health and happiness.
In the last twenty years, it has become increasingly clear from scientific research that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways.
On the contrary, the cellular and molecular mechanisms underlying all these integrated effects still remain obscure. Single molecules, such as the brain derived neurotrophic factor (BDNF) or even lactate, have been referred to as causative factors and been examined at a molecular level in different cells. Most of the web of factors involved in the molecular signalling upon exercise is suspected to be centrally controlled by the brain, which has been indeed reported to be deeply modified by physical activity. Lately, the chromatin structure and epigenetic marks (and thus gene expression) have been reported to be modulated upon physical activity and help in the treatment of pathologies as different as Alzheimer’s disease, diabetes, and multiple sclerosis.
Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level. For this reason, we decided to bring together a collection of research articles and reviews from which new ideas could be obtained and shared.
Prof. Italia Di Liegro
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- physical exercise
- transgenerational inheritance
- brain cells
- healthy lifestyle
- central control of metabolism