Special Issue "Functional Role of BRCA 1 and 2 in Tissue Maintenance and Neoplasia"
Deadline for manuscript submissions: 20 July 2020.
Interests: stem cells in breast morphogenesis and cancer
Breast cancer 1 and 2 susceptibility genes (BRCA1 and BRCA2) are important tumor suppressor genes that have a major impact on the mechanisms of genome protection. Their proteins are important caretakers in cells and tissue maintenance through their role in error-free DNA repair through homologous recombination. Mutations in BRCA1 and BRCA2 are known to predispose and cause breast cancer and other forms of cancer such as ovarian, pancreas and prostate cancer. These mutations can be both somatic and hereditary (germline), which affect individuals and families and induce a high incidence of certain cancer types, including breast cancer.
This Special Issue will highlight the recent advances in BRCA1 and BRCA2 cancer research, focusing on both somatic and germline mutations, the transcription regulation of BRCA proteins and their functional role within distinct subtypes of breast and other cancer types in tissue maintenance and stem cell biology.
We welcome the submission of reviews, perspectives, short communications, and research articles.
Prof. Thorarinn Gudjonsson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- transcription regulation of BRCA genes
- tissue stem cells
- somatic and germline BRCA mutations
- breast cancer
- BRCA target tissues
- BRCA interacting proteins