Special Issue "Genetic and Molecular Mechanisms in Plant-derived Compounds for Industrial Purposes"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Plant Genetics and Genomics".

Deadline for manuscript submissions: 1 March 2020.

Special Issue Editors

Dr. Maria Manuela Rigano
Guest Editor
Department of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Naples, Italy.
Tel. (+39) 081 2539208
Dr. Christoph Crocoll
Guest Editor
Department of Plant and Environmental Sciences, Section for Molecular Plant Biology, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
Dr. Teresa Docimo
Guest Editor
CNR-IBBR Institute of Bioscience and BioResources Via Universita' 133, 80055 Portici, Naples, Italy.

Special Issue Information

Dear Colleagues,

Plants produce a terrific panoply of metabolites involved in many biological mechanisms, which can be exploited for the wellbeing of humans and environment. This array of compounds includes valuable molecules with a broad spectrum of application. As green factories, plants may provide bioactive molecules, proteins, carbohydrates and biopolymers for a sustainable, large-scale production of commodities such as pharmaceuticals, antioxidants, food, feed, chemicals, materials and biofuels for multiple industrial processes. Insights on biosynthesis, catabolism and regulation of these bioactive molecules can be pursued through advanced molecular tools coupled with metabolomics, which in turn allow an accurate identification of the main biosynthetic genes and molecular mechanisms involved in the accumulation of these compounds. Moreover, synergy between disciplines also apparently distant such as plant physiology, pharmacology, ‘omic sciences, bioinformatics and nanotechnology, paves the path to the emergence of novel applications of plants as metabolic factories of bioactive compounds for wide-ranging purposes.

The Forthcoming Special Issue intends to deepen knowledge on plant-based compounds biosynthesis and its orchestration and on innovative approaches of plant biotechnology highly relevant for the development of sustainable improvements in food quality, nutrition, public health and bioenergy.

Dr. Maria Manuela Rigano
Dr. Christoph Crocoll
Dr. Teresa Docimo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Vegetables, crop, and tree
  • Bioactive compounds
  • Genomics
  • Metabolomics
  • Genome editing
  • Medicinal plants
  • Plant Natural products
  • Plant biotechnology
  • Biofortification

Published Papers (1 paper)

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Open AccessArticle
Ectopic Expression of Multiple Chrysanthemum (Chrysanthemum × morifolium) R2R3-MYB Transcription Factor Genes Regulates Anthocyanin Accumulation in Tobacco
Genes 2019, 10(10), 777; https://doi.org/10.3390/genes10100777 - 04 Oct 2019
The generation of chrysanthemum (Chrysanthemum × morifolium) flower color is mainly attributed to the accumulation of anthocyanins. In the anthocyanin biosynthetic pathway in chrysanthemum, although all of the structural genes have been cloned, the regulatory function of R2R3-MYB transcription factor (TF) [...] Read more.
The generation of chrysanthemum (Chrysanthemum × morifolium) flower color is mainly attributed to the accumulation of anthocyanins. In the anthocyanin biosynthetic pathway in chrysanthemum, although all of the structural genes have been cloned, the regulatory function of R2R3-MYB transcription factor (TF) genes, which play a crucial role in determining anthocyanin accumulation in many ornamental crops, still remains unclear. In our previous study, four light-induced R2R3-MYB TF genes in chrysanthemum were identified using transcriptomic sequencing. In the present study, we further investigated the regulatory functions of these genes via phylogenetic and alignment analyses of amino acid sequences, which were subsequently verified by phenotypic, pigmental, and structural gene expression analyses in transgenic tobacco lines. As revealed by phylogenetic and alignment analyses, CmMYB4 and CmMYB5 were phenylpropanoid and flavonoid repressor R2R3-MYB genes, respectively, while CmMYB6 was an activator of anthocyanin biosynthesis, and CmMYB7 was involved in regulating flavonol biosynthesis. Compared with wild-type plants, the relative anthocyanin contents in the 35S:CmMYB4 and 35S:CmMYB5 tobacco lines significantly decreased (p < 0.05), while for 35S:CmMYB6 and 35S:CmMYB7, the opposite result was obtained. Both in the 35S:CmMYB4 and 35S:CmMYB5 lines, the relative expression of several anthocyanin biosynthetic genes in tobacco was significantly downregulated (p < 0.05); on the contrary, several genes were upregulated in the 35S:CmMYB6 and 35S:CmMYB7 lines. These results indicate that CmMYB4 and CmMYB5 negatively regulate anthocyanin biosynthesis in chrysanthemum, while CmMYB6 and CmMYB7 play a positive role, which will aid in understanding the complex mechanism regulating floral pigmentation in chrysanthemum and the functional divergence of the R2R3-MYB gene family in higher plants. Full article
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