Chromosome-Centric View of the Genome Organization and Evolution

Dear Colleagues,

The development of next generation sequencing technologies in the last decade has led to obtaining highly-fragmented genome assemblies for numerous organisms. The quality of genome assemblies significantly varies among species, depending of the abundance of the repetitive elements and levels of genetic polymorphism. As a result, many important problems in genome biology remain unresolved, without understanding how the genome is organized at the level of the chromosomes. Recent advances in genome and chromosome technologies, including long-read sequencing, Hi-C scaffoding,  chromosome flow sorting, and physical and optical mapping, allow for obtaining genome assemblies at the level of complete chromosomes. Such assemblies provide new opportunities to study chromosome organization and evolution, structural genome variations, gene movements, sex-biased gene expression, epigenomic modifications, and long-range chromatin interactions.

In this Special Issue, we would like to invite submissions of original research and review articles, with a special focus on chromosomes in our understanding of the genome structure, function, and evolution. Any articles, from the development of the new technologies to comprehensive genome analyses, are welcome.   

Dr. Maria Sharakhova
Dr. Vladimir Trifinov
Guest Editors

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