Special Issue "Genetics of Prader-Willi syndrome"
Deadline for manuscript submissions: closed (1 November 2019).
Interests: Prader-Willi syndrome; fragile X syndrome; microdeletion syndromes; autism spectrum disorders; genetics of autism; obesity and intellectual disability; chromosomal microarray analysis; next generation sequencing; delineation of rare genetic disorders; genotype-phenotype relationships
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Special Issue in International Journal of Molecular Sciences: Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019
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Interests: Chromosome 15 imprinting disorders, fragile X syndrome, Newborn screening, diagnostic testing, FMR1, SNRPN, mosaicism, chromosomal abnormalities, epigenetics, intellectual disability, autism spectrum disorders, genotype-phenotype relationships
Prader–Willi syndrome (PWS) is a complex genomic imprinting disorder associated with a spectrum of medical, cognitive, behavioural, and psychiatric problems and is also the most common cause of life-threatening obesity that can be effectively treated with hormone therapy and restricted diet, if detected early. PWS is usually caused by the loss of the paternally inherited 15q11.2-q13 region and abnormal expression of genes within that region and beyond. While some genotype–phenotype correlations with delineation of clinical characteristics and natural history have emerged when comparing the three main molecular classes of PWS (maternal uniparental disomy (UPD) 15, imprinting centre defect, and deletion of paternal 15q11-q13), better awareness and informative biomarkers are still needed. These could facilitate early diagnosis, counseling, prognostic testing, as well as patient stratification for clinical trials, to improve outcomes for the affected children and their families.
This Special Issue will comprise reviews and original research articles focused on the recent advances of genetics/genomics, testing, and epigenetic processes along with clinical description, co-morbidities, and natural history of Prader–Willi syndrome (PWS). Current and future directions with focus on improved screening, diagnosis, and treatment will be addressed in this rare neurodevelopmental genetic imprinting disorder influenced by the PWS genetic subtypes.
Prof. Merlin G. Butler
Prof. David E. Godler
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Genotype–phenotype relationships
- Natural history
- Genetic testing
- Behavioural issues
- Intellectual functioning