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Genes, Volume 10, Issue 11

2019 November - 112 articles

Cover Story: Globally, we find ourselves in the midst of a biodiversity crisis and in need of conservation tools to help preserve the species that remain. Advances in sequencing technologies and reduction in sequencing costs have given rise to the era of genomics. Whole-genome data can provide answers to a variety of crucial conservation questions including understanding demography and population structure, minimising inbreeding, maximising adaptive potential, and identifying the basis of important phenotypic traits. Incorporation of genomic data to assist in the recovery of threatened species is vital; however, it is often unclear how reference genomes facilitate the use of genomics in management practice. In this review we use the Tasmanian devil as a model to demonstrate specific examples of how a reference genome can aid management actions in the conservation of threatened species. View this paper.
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Articles (112)

  • Review
  • Open Access
14 Citations
6,808 Views
33 Pages

Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription

  • Izabella Bajusz,
  • Surya Henry,
  • Enikő Sutus,
  • Gergő Kovács and
  • Melinda K. Pirity

19 November 2019

Separation of germline cells from somatic lineages is one of the earliest decisions of embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors, which are not transcribed in the soma normally, but a number of testis-spec...

  • Article
  • Open Access
24 Citations
4,994 Views
16 Pages

SNP-Based Genetic Risk Score Modeling Suggests No Increased Genetic Susceptibility of the Roma Population to Type 2 Diabetes Mellitus

  • Nardos Abebe Werissa,
  • Peter Piko,
  • Szilvia Fiatal,
  • Zsigmond Kosa,
  • Janos Sandor and
  • Roza Adany

19 November 2019

Background: In a previous survey, an elevated fasting glucose level (FG) and/or known type 2 diabetes mellitus (T2DM) were significantly more frequent in the Roma population than in the Hungarian general population. We assessed whether the distributi...

  • Article
  • Open Access
5 Citations
3,922 Views
17 Pages

Analysis of Soybean Somatic Embryogenesis Using Chromosome Segment Substitution Lines and Transcriptome Sequencing

  • Si-Nan Li,
  • Peng Cheng,
  • Yun-Qi Bai,
  • Yan Shi,
  • Jing-Yao Yu,
  • Rui-Chao Li,
  • Run-Nan Zhou,
  • Zhan-Guo Zhang,
  • Xiao-Xia Wu and
  • Qing-Shan Chen

19 November 2019

Soybean is an important cash crop that is widely used as a source of vegetable protein and edible oil. The regeneration ability of soybean directly affects the application of biotechnology. In this study, we used the exogenous hormone 2,4-D to treat...

  • Article
  • Open Access
13 Citations
5,025 Views
18 Pages

19 November 2019

Leaf premature senescence largely determines maize (Zea mays L.) grain yield and quality. A natural recessive premature-senescence mutant was selected from the breeding population, and near-isogenic lines were constructed using Jing24 as the recurren...

  • Article
  • Open Access
27 Citations
5,535 Views
10 Pages

Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children

  • Paula Costa-Urrutia,
  • Valentina Colistro,
  • Angélica Saraí Jiménez-Osorio,
  • Helios Cárdenas-Hernández,
  • Jacqueline Solares-Tlapechco,
  • Miryam Ramirez-Alcántara,
  • Julio Granados,
  • Iván de Jesús Ascencio-Montiel and
  • Martha Eunice Rodríguez-Arellano

19 November 2019

Background: Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS). Objective. We pe...

  • Article
  • Open Access
28 Citations
4,871 Views
14 Pages

Coding and Non-Coding RNA Abnormalities in Bipolar Disorder

  • Jurjen J. Luykx,
  • Fabrizio Giuliani,
  • Giuliano Giuliani and
  • Jan Veldink

19 November 2019

The molecular mechanisms underlying bipolar disorder (BPD) have remained largely unknown. Postmortem brain tissue studies comparing BPD patients with healthy controls have produced a heterogeneous array of potentially implicated protein-coding RNAs....

  • Article
  • Open Access
19 Citations
4,329 Views
13 Pages

Transcriptomic Analysis Reveals Involvement of the Macrophage Migration Inhibitory Factor Gene Network in Duchenne Muscular Dystrophy

  • Salvo Danilo Lombardo,
  • Emanuela Mazzon,
  • Katia Mangano,
  • Maria Sofia Basile,
  • Eugenio Cavalli,
  • Santa Mammana,
  • Paolo Fagone,
  • Ferdinando Nicoletti and
  • Maria Cristina Petralia

18 November 2019

Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory r...

  • Review
  • Open Access
3 Citations
3,335 Views
9 Pages

18 November 2019

In the ciliate Stylonychia, somatic macronuclei differentiate from germline micronuclei during sexual reproduction, accompanied by developmental sequence reduction. Concomitantly, over 95% of micronuclear sequences adopt a heterochromatin structure c...

  • Article
  • Open Access
29 Citations
5,953 Views
18 Pages

NF-YA Overexpression in Lung Cancer: LUSC

  • Eugenia Bezzecchi,
  • Mirko Ronzio,
  • Diletta Dolfini and
  • Roberto Mantovani

17 November 2019

The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl (“long”) and NF-YAs (“short”). Little is known about the expression levels of NF-Y su...

  • Article
  • Open Access
63 Citations
7,712 Views
24 Pages

Genome-Wide Runs of Homozygosity, Effective Population Size, and Detection of Positive Selection Signatures in Six Chinese Goat Breeds

  • Rabiul Islam,
  • Yefang Li,
  • Xuexue Liu,
  • Haile Berihulay,
  • Adam Abied,
  • Gebremedhin Gebreselassie,
  • Qing Ma and
  • Yuehui Ma

17 November 2019

Detection of selection footprints provides insight into the evolution process and the underlying mechanisms controlling the phenotypic diversity of traits that have been exposed to selection. Selection focused on certain characters, mapping certain g...

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Genes - ISSN 2073-4425