Special Issue "ALT: From Telomere Maintenance Mechanisms to Proposed Therapies"
Deadline for manuscript submissions: closed (15 November 2019).
Interests: Tionizing radiation; electromagnetic waves; radiation biology; chromosome aberrations; micronuclei induction; chromosome structure; cellular senescence
Special Issues and Collections in MDPI journals
Interests: genotoxicity; senescence; telomerase inhibitors; telomere biology; telomere evolution
Interests: telomeric G-quadruplex; telomere and telomerase targeting; ALT; cancer; DNA damage; ionizing radiations
Alternative Lengthening of Telomeres (ALT) is one of the Telomere Maintenance Mechanisms (TMM). Because the mechanism was unknown at the beginning, many studies were aimed to point out the molecular markers of ALT, since the only distinctive known feature at the time was telomere length maintenance in absence of telomerase. Nowadays, ALT cells have been characterized by different markers widely accepted, including chromatin modifications, but the mechanism and the events triggering ALT are still little known. Several experimental evidences came in favour of a recombinogenic mechanism, fuelling the need to clarify whether ALT is nothing but homologous recombination (HR) or it is a telomere-specific type of HR. The complexity of the ALT mechanisms is one of the keys to unfold the heterogeneous behavior of ALT tumors in terms of disease progression and response to treatment. As a consequence, while specific telomerase drugs have been discovered and are presently employed in clinical applications, the therapeutic relevance of molecular players involved in ALT is still debated. Furthermore, considering the role of telomere in chromosome structure and therefore in genome stability and in tumor progression, the mechanisms involved in telomere maintenance need to be clarified and great efforts are needed to allow an in-depth comprehension of the ALT molecular mechanisms; especially in order to develop specific and effective anticancer strategies.
Prof. Antonella Sgura
Dr. Ion Udroiu
Dr. Francesco Berardinelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- telomere biology
- alternative lengthening of telomeres
- DNA damage
- telomere maintenance mechanism
- genome stability