Special Issue "ALT: From Telomere Maintenance Mechanisms to Proposed Therapies"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 15 November 2019.

Special Issue Editors

Guest Editor
Prof. Antonella Sgura Website E-Mail
Department of Science, University of Rome "Roma Tre", Rome, Italy
Interests: Telomere, oxidative stress, genotoxicity, epigenetic, ALT in human primary fibroblasts, senescence, DNA damage, ionizing radiations
Guest Editor
Dr. Ion Udroiu E-Mail
Department of Science, University of Rome "Roma Tre", Rome, Italy
Interests: Genotoxicity, senescence, telomerase inhibitors, telomere biology, telomere evolution.
Guest Editor
Dr. Francesco Berardinelli E-Mail
Department of Science, University of Rome "Roma Tre", Rome, Italy
Interests: Telomeric G-quadruplex, telomere and telomerase targeting, ALT, cancer, DNA damage, ionizing radiations.

Special Issue Information

Dear Colleagues,

Alternative Lengthening of Telomeres (ALT) is one of the Telomere Maintenance Mechanisms (TMM). Because the mechanism was unknown at the beginning, many studies were aimed to point out the molecular markers of ALT, since the only distinctive known feature at the time was telomere length maintenance in absence of telomerase. Nowadays, ALT cells have been characterized by different markers widely accepted, including chromatin modifications, but the mechanism and the events triggering ALT are still little known. Several experimental evidences came in favour of a recombinogenic mechanism, fuelling the need to clarify whether ALT is nothing but homologous recombination (HR) or it is a telomere-specific type of HR. The complexity of the ALT mechanisms is one of the keys to unfold the heterogeneous behavior of ALT tumors in terms of disease progression and response to treatment. As a consequence, while specific telomerase drugs have been discovered and are presently employed in clinical applications, the therapeutic relevance of molecular players involved in ALT is still debated. Furthermore, considering the role of telomere in chromosome structure and therefore in genome stability and in tumor progression, the mechanisms involved in telomere maintenance need to be clarified and great efforts are needed to allow an in-depth comprehension of the ALT molecular mechanisms; especially in order to develop specific and effective anticancer strategies.

Prof. Antonella Sgura
Dr. Ion Udroiu
Dr. Francesco Berardinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • telomere biology
  • alternative lengthening of telomeres
  • telomerase
  • DNA damage
  • cancer
  • telomere maintenance mechanism
  • chromatin
  • genome stability
  • chromosome

Published Papers (1 paper)

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Research

Open AccessArticle
BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells
Genes 2019, 10(9), 697; https://doi.org/10.3390/genes10090697 (registering DOI) - 10 Sep 2019
Abstract
BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion [...] Read more.
BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion triggers TERRA hyperexpression and alternative lengthening mechanisms (ALT) in colon cancer cells in presence of telomerase activity. This finding opens the question if cancer patients bearing BRCA2 germline or sporadic mutation are suitable for anti-telomerase therapies, or how ALT activation could influence the short or long-term response to anti-PARP inhibitors or anti-G-quadruplex therapies. Full article
(This article belongs to the Special Issue ALT: From Telomere Maintenance Mechanisms to Proposed Therapies)
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