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Cancers, Volume 17, Issue 2

2025 January-2 - 174 articles

Cover Story: Neuroendocrine neoplasms (NENs) exhibit diverse biological behaviors, ranging from indolent to highly aggressive forms, with unique tumor-associated complications such as venous thromboembolisms (VTEs). This paper systematically reviews the incidence, types, and clinical outcomes of VTEs in NEN patients, reporting a pooled prevalence of 11.1% and a range of 7.5–33%. Pancreatic and functioning NENs demonstrate the highest thrombotic burden, particularly in the advanced or poorly differentiated stages. Early recognition, risk stratification, and the targeted management of VTEs are critical for improving outcomes, while further research is needed to elucidate underlying mechanisms and optimize therapeutic strategies. View this paper
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Articles (174)

  • Systematic Review
  • Open Access
5 Citations
6,035 Views
12 Pages

Impact of Physical Exercise on Breast Cancer-Related Lymphedema and Non-Invasive Measurement Tools: A Systematic Review

  • Marta Arias-Crespo,
  • Rubén García-Fernández,
  • Natalia Calvo-Ayuso,
  • Cristian Martín-Vázquez,
  • Maria de Fátima da Silva Vieira Martins and
  • Enedina Quiroga-Sánchez

20 January 2025

Background/Objectives: Breast cancer-related lymphedema (BCRL) is a chronic disease with lasting effects, making it one of the most feared sequelae of breast cancer with significant personal and social impacts. Therapeutic exercises play a fundamenta...

  • Article
  • Open Access
5 Citations
2,308 Views
19 Pages

20 January 2025

Background: The accurate staging of multiple myeloma (MM) is essential for optimizing treatment strategies, while predicting the progression of asymptomatic patients, also referred to as monoclonal gammopathy of undetermined significance (MGUS), to s...

  • Review
  • Open Access
4 Citations
6,096 Views
19 Pages

A Comprehensive Approach to Neoadjuvant Treatment of Locally Advanced Rectal Cancer

  • Annalice Gandini,
  • Stefania Sciallero,
  • Valentino Martelli,
  • Chiara Pirrone,
  • Silvia Puglisi,
  • Malvina Cremante,
  • Massimiliano Grassi,
  • Valeria Andretta,
  • Giuseppe Fornarini and
  • Alessandro Pastorino
  • + 5 authors

20 January 2025

At the end of the past century, the introduction of Total Mesorectal Excision (TME), preceded by either short-course radiotherapy (SCRT) or chemoradiation (CRT), established the new standard of care for locally advanced rectal cancer (LARC). Recently...

  • Article
  • Open Access
4 Citations
1,983 Views
12 Pages

20 January 2025

Background/Objectives: Accurate diagnosis is essential to avoid unnecessary procedures for thyroid incidentalomas (TIs). Advances in radiomics and machine learning applied to medical imaging offer promise for assessing thyroid nodules. This study uti...

  • Systematic Review
  • Open Access
3 Citations
1,598 Views
16 Pages

20 January 2025

Objective: The aim of this systematic review and meta-analysis was to qualitatively and quantitatively evaluate the current evidence on the significance of the loss of early stages of oral carcinogenesis in lesions diagnosed according to clinical and...

  • Article
  • Open Access
2 Citations
2,483 Views
26 Pages

Risk Factors for Treatment Toxicity and High Side Effect Burden Among Breast Cancer Survivors: A Retrospective Chart Review

  • Muna Alkhaifi,
  • Elwyn Zhang,
  • Malika Peera,
  • Katarzyna Jerzak,
  • Gregory Czarnota,
  • Andrea Eisen,
  • Amanda Roberts,
  • Carlos Amir Carmona-Gonzalez,
  • Rosanna Pezo and
  • Sonal Gandhi

20 January 2025

Background/Objectives: This study describes the sequelae, side effects, and toxicities experienced by Canadian breast cancer survivors at a breast cancer survivorship clinic at a tertiary academic cancer centre and identifies potential risk factors w...

  • Article
  • Open Access
2 Citations
2,302 Views
9 Pages

Proton Beam Therapy for Advanced Periocular Skin Cancer: An Eye-Sparing Approach

  • Yingying Zhang,
  • Isabela C. S. Lima,
  • Alessandra A. Woo,
  • Stephen Zieminski,
  • Judith A. Adams,
  • Megan A. Hughes and
  • Annie W. Chan

20 January 2025

Background/Objectives: The management of periocular skin malignancies presents a unique challenge. Proton beam therapy, due to its sharp dose fall-off, allows for the delivery of a tumoricidal dose to the tumor while sparing adjacent normal tissues....

  • Review
  • Open Access
3 Citations
6,072 Views
36 Pages

Immune-Based and Novel Therapies in Variant Histology Renal Cell Carcinomas

  • Justin W. Miller,
  • Jeffrey S. Johnson,
  • Christopher Guske,
  • Gowtam Mannam,
  • Firas Hatoum,
  • Michelle Nassar,
  • Marine Potez,
  • Adnan Fazili,
  • Philippe E. Spiess and
  • Jad Chahoud

20 January 2025

Renal cell carcinoma (RCC) is a heterogeneous disease that represents the most common type of kidney cancer. The classification of RCC is primarily based on distinct morphological and molecular characteristics, with two broad categories: clear cell R...

  • Correction
  • Open Access
1,299 Views
2 Pages

Correction: Alaei et al. Therapeutic Potential of Targeting the Cytochrome P450 Enzymes Using Lopinavir/Ritonavir in Colorectal Cancer: A Study in Monolayers, Spheroids and In Vivo Models. Cancers 2023, 15, 3939

  • Maryam Alaei,
  • Seyedeh Elnaz Nazari,
  • Ghazaleh Pourali,
  • AliReza Asadnia,
  • Mehrdad Moetamani-Ahmadi,
  • Hamid Fiuji,
  • Hamid Tanzadehpanah,
  • Fereshteh Asgharzadeh,
  • Fatemeh Babaei and
  • Amir Avan
  • + 8 authors

20 January 2025

Error in Figure and Text [...]

  • Article
  • Open Access
2 Citations
1,831 Views
20 Pages

Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene

  • Tetsuya Ikawa,
  • Emi Yamazaki,
  • Ryo Amagai,
  • Yumi Kambayashi,
  • Mana Sekine,
  • Takuya Takahashi,
  • Yoshihide Asano and
  • Taku Fujimura

20 January 2025

Background: Cutaneous T-cell lymphoma (CTCL) is a type of non-Hodgkin’s lymphoma that primarily affects the skin, rich in hyaluronic acid (HA). HA is a component of the extracellular matrix in the dermis and likely affects the development of CT...

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Cancers - ISSN 2072-6694