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Cancers, Volume 17, Issue 2

2025 January-2 - 174 articles

Cover Story: Neuroendocrine neoplasms (NENs) exhibit diverse biological behaviors, ranging from indolent to highly aggressive forms, with unique tumor-associated complications such as venous thromboembolisms (VTEs). This paper systematically reviews the incidence, types, and clinical outcomes of VTEs in NEN patients, reporting a pooled prevalence of 11.1% and a range of 7.5–33%. Pancreatic and functioning NENs demonstrate the highest thrombotic burden, particularly in the advanced or poorly differentiated stages. Early recognition, risk stratification, and the targeted management of VTEs are critical for improving outcomes, while further research is needed to elucidate underlying mechanisms and optimize therapeutic strategies. View this paper
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Articles (174)

  • Review
  • Open Access
1 Citations
3,557 Views
18 Pages

Lymphangioleiomyomatosis and Pregnancy—Do We Have All the Answers for a Woman Who Desires to Conceive?—Literature Review

  • Ancuta-Alina Constantin,
  • Andreea Dumitrita Gaburici,
  • Andreea Nicoleta Malaescu,
  • Ana-Luiza Iorga,
  • Christiana Diana Maria Dragosloveanu,
  • Mircea-Octavian Poenaru,
  • Gabriel-Petre Gorecki,
  • Mihaela Amza,
  • Mihai-Teodor Georgescu and
  • Romina-Marina Sima
  • + 2 authors

20 January 2025

Lymphangioleiomyomatosis (LAM) is a rare, progressive, and poor-prognosis systemic disorder that primarily affects women of reproductive age, with a higher prevalence among individuals of Caucasian origin. However, there are limited reliable data on...

  • Article
  • Open Access
1 Citations
2,375 Views
17 Pages

Computed Tomography-Image-Based Glioma Grading Using Radiomics and Machine Learning: A Proof-of-Principle Study

  • Melike Bilgin,
  • Sabriye Sennur Bilgin,
  • Burak Han Akkurt,
  • Walter Heindel,
  • Manoj Mannil and
  • Manfred Musigmann

20 January 2025

Background/Objectives: In recent years, numerous studies have been published on determining the WHO grade of central nervous system (CNS) tumors using machine learning algorithms. These studies are usually based on magnetic resonance imaging (MRI) an...

  • Article
  • Open Access
1 Citations
1,333 Views
11 Pages

20 January 2025

Background: Patients undergoing endoscopic submucosal dissection under monitored anesthesia care (MAC) with remimazolam may develop respiratory distress during the procedure. In these cases, low doses of flumazenil improved respiratory distress witho...

  • Review
  • Open Access
13 Citations
6,163 Views
34 Pages

From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial Cancer

  • Thulo Molefi,
  • Lloyd Mabonga,
  • Rodney Hull,
  • Motshedisi Sebitloane and
  • Zodwa Dlamini

20 January 2025

Endometrial cancer (EC), a prevalent gynecological malignancy, presents significant challenges due to its genetic complexity and heterogeneity. The genomic landscape of EC is underpinned by genetic alterations, such as mutations in PTEN, PIK3CA, and...

  • Article
  • Open Access
2 Citations
1,709 Views
18 Pages

20 January 2025

Oxidative stress is universal to all cell types, including cancer. It is elicited by a surplus of reactive oxygen species (ROS) or a reduced cellular ability to defend against those. At low levels (oxidative eustress), this induces altered cellular s...

  • Review
  • Open Access
8 Citations
3,808 Views
29 Pages

Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies

  • Tamara Vujović,
  • Tina Paradžik,
  • Sanja Babić Brčić and
  • Roberto Piva

20 January 2025

Algae are a rich source of bioactive compounds that have a wide range of beneficial effects on human health and can show significant potential in the treatment of hematological malignancies such as leukemia, lymphoma, and multiple myeloma. These dise...

  • Review
  • Open Access
3 Citations
3,615 Views
17 Pages

20 January 2025

T-cell redirecting therapies, which include chimeric antigen receptor T-cells (CAR-Ts) and bispecific antibodies (BSAs), have revolutionized the treatment of relapsed\refractory large B-cell lymphoma (LBCL). Expanding clinical experience with these a...

  • Review
  • Open Access
2 Citations
3,487 Views
16 Pages

Urogenital Cancer Epidemiology in Poland (1980–2020): A Narrative Review

  • Iwona Wnętrzak,
  • Joanna Didkowska,
  • Roman Sosnowski,
  • Mateusz Czajkowski,
  • Dawid Sigorski,
  • Bartosz Małkiewicz,
  • Piotr Marczyński,
  • Jarosław Jaskulski,
  • Piotr Kania and
  • Robert Nowakowski
  • + 5 authors

20 January 2025

Despite advances in prophylaxis, early diagnosis, and treatment, urogenital cancers represent a significant challenge to public health in Poland due to their relatively high prevalence and mortality rates. This narrative review aims to explore contem...

  • Article
  • Open Access
6 Citations
3,536 Views
12 Pages

Deep Learning-Based Glioma Segmentation of 2D Intraoperative Ultrasound Images: A Multicenter Study Using the Brain Tumor Intraoperative Ultrasound Database (BraTioUS)

  • Santiago Cepeda,
  • Olga Esteban-Sinovas,
  • Vikas Singh,
  • Prakash Shetty,
  • Aliasgar Moiyadi,
  • Luke Dixon,
  • Alistair Weld,
  • Giulio Anichini,
  • Stamatia Giannarou and
  • Rosario Sarabia
  • + 11 authors

19 January 2025

Background: Intraoperative ultrasound (ioUS) provides real-time imaging during neurosurgical procedures, with advantages such as portability and cost-effectiveness. Accurate tumor segmentation has the potential to substantially enhance the interpreta...

  • Article
  • Open Access
5 Citations
4,150 Views
15 Pages

Initial Use Experience of Durvalumab Plus Gemcitabine and Cisplatin for Advanced Biliary Tract Cancer in a Japanese Territory Center

  • Kento Shionoya,
  • Atsushi Sofuni,
  • Shuntaro Mukai,
  • Yoshiya Yamauchi,
  • Takayoshi Tsuchiya,
  • Reina Tanaka,
  • Ryosuke Tonozuka,
  • Kenjiro Yamamoto,
  • Kazumasa Nagai and
  • Takao Itoi
  • + 5 authors

19 January 2025

Background: Biliary tract cancers (BTCs), including gallbladder and bile duct cancers, have a poor prognosis. Recent advances in chemotherapy, such as using targeted drugs for specific gene mutations, have improved outcomes. Gemcitabine plus cisplati...

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Cancers - ISSN 2072-6694