Toxins, Volume 8, Issue 3 (March 2016) – 31 articles
Cover Story (view full-size image): The threat of antibiotic resistance in bacterial pathogens has prompted calls for alternative therapeutic approaches less likely to lead to resistance. Staphylococcus aureus expresses an arsenal of virulence factors to survive the onslaught of host immune responses. However, treating an S. aureus infection is difficult due to the bacteria’s resistance to several antibiotics. Nevertheless, recent advances in understanding S. aureus virulence determinants have enabled the development of anti-virulence therapies. Kong et al. review two prospective strategies: a direct approach that specifically targets S. aureus toxins and an indirect approach to target the regulatory mechanism of S. aereus virulence factors. View this article.
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