Table of Contents
Toxins, Volume 8, Issue 4 (April 2016)
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Cover Story (view full-size image) Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe [...] Read more. Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals. TcsL glucosylates small GTPases lead to cell death. The catalytic domain of TcsL (TcsL-cat) was found to preferentially bind to phosphatidylserine (PS)-containing membranes and to increase the glucosylation of Rac and Ras anchored to lipid membrane. The PS binding site is localized on the tip of the four-helix bundle which is rich in positively charged amino acids. Functional PS-binding site is required for TcsL-cat binding to the plasma membrane and subsequent cytotoxicity. View this article.