Table of Contents
Toxins, Volume 10, Issue 3 (March 2018)
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Cover Story (view full-size image) The cover illustrates the crystal structure of five single domain antibody fragments (Nanobodies, [...] Read more. The cover illustrates the crystal structure of five single domain antibody fragments (Nanobodies, blue cartoon representation) in complex with the B subunit of Shiga toxin 2a (Stx2a, grey surface representation). The Nanobodies impair the interaction of Stx2a with the Gb3 receptor by physically blocking the toxin’s ligand binding sites 1, 2, and 3 (highlighted in yellow, orange, and red, respectively). Given the causal link between Stx2a production by enterohemorrhagic E. coli (EHEC) and severe pathology in humans, this inhibitory Nanobody lead may pave the road towards a novel anti-Stx2a treatment in humans. View the paper here.