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Viruses, Volume 17, Issue 5

May 2025 - 149 articles

Cover Story: Human papillomaviruses (HPVs) comprise a large family of non-enveloped DNA viruses. Common to most DNA viruses, deposition of the viral DNA within the host nucleus is necessary for infection. Unique to HPVs, this is accomplished through the delivery of relatively intact capsids within transport vesicles that associate with the host’s mitotic chromatin. In this study, we explored the ER as the source of these vesicles. HPV16 colocalized with components of the ER-generated COPII pathway and siRNA-mediated silencing of this pathway decreased infection. Interestingly, prevention of COPII-mediated egress from the ER resulted in relocalization of the capsids to vesicles containing the autophagic scaffold protein FIP200. We believe that these data reflect a balance between COPII vesicle generation and autophagosome biogenesis in HPV trafficking. View this paper
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Articles (149)

  • Review
  • Open Access
2 Citations
1,907 Views
17 Pages

21 May 2025

Vaccination plays a pivotal role in the control and prevention of animal infectious diseases. However, no efficient and safe universal vaccines are currently registered for major pathogens such as influenza A virus, foot-and-mouth disease virus (FMDV...

  • Article
  • Open Access
1 Citations
1,127 Views
20 Pages

Epidemiological and Molecular Surveillance of Aichi Virus A at Different Stages of Sewage Treatment: A One-Year Study in the Southeast of Brazil

  • Mariah C. A. do Nascimento,
  • Camila R. Rosa,
  • Meriane Demoliner,
  • Dayla B. Geraldini,
  • Guilherme R. F. Campos,
  • Daniela M. Quevedo,
  • Rafael N. Miceli,
  • Fernando R. Spilki,
  • João Pessoa Araújo and
  • Marilia F. Calmon
  • + 1 author

21 May 2025

Enteric viruses, such as the Aichi virus (AiV), pose a potential health risk due to their high excretion rates through fecal elimination, limited removal during treatment processes, and prolonged survival, highlighting the need to assess the potentia...

  • Review
  • Open Access
1 Citations
2,381 Views
20 Pages

The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion

  • Qianxun Liu,
  • Shantong Peng,
  • Jiani Wei and
  • Zhenzhen Xie

20 May 2025

Tripartite motif (TRIM) 25 is a member of the TRIM E3 ubiquitin ligase family, which plays multiple roles in anti-tumor and antiviral defenses through various pathways. Its RBCC and SPRY/PRY domains work cooperatively for its oligomerization and subs...

  • Article
  • Open Access
1,829 Views
23 Pages

20 May 2025

Highly pathogenic avian influenza (HPAI) A/H5N1 viruses threaten animal and human health worldwide. The first documented cases in the Middle East were reported in 2005; however, despite extensive phylogenetic studies, there is limited information on...

  • Article
  • Open Access
1,477 Views
18 Pages

Progressive Adaptation of Subtype H6N1 Avian Influenza Virus in Taiwan Enhances Mammalian Infectivity, Pathogenicity, and Transmissibility

  • Zuoyi Zheng,
  • Xifeng Chen,
  • Rutian Zheng,
  • Zhigang Yan,
  • Long Li,
  • Rirong Chen,
  • Lifeng Li,
  • Yongmei Liu,
  • Yi Guan and
  • Huachen Zhu

20 May 2025

The interspecies transmission of avian influenza viruses remains a significant public health concern. H6 viruses have gained attention following the first human infection by a chicken-origin H6N1 virus (A/Taiwan/02/2013, Hu/13), highlighting their zo...

  • Article
  • Open Access
1 Citations
1,240 Views
15 Pages

Characterization of an Emerging Recombinant Duck Circovirus in Northern Vietnam, 2023–2024

  • Hieu Van Dong,
  • Dai Quang Trinh,
  • Giang Huong Thi Tran,
  • Thanh Thi Vu,
  • Thinh Hung Ba Nguyen,
  • Amonpun Rattanasrisomporn,
  • Dao Anh Tran Bui and
  • Jatuporn Rattanasrisomporn

20 May 2025

This study aimed to characterize the duck circovirus circulating in Northern Vietnam based on complete genome sequences. Between 2023 and 2025, 45 pooled tissue samples were collected from nine duck flocks in several provinces in Northern Vietnam. Of...

  • Article
  • Open Access
1,577 Views
14 Pages

Prevalence of Doravirine Resistance Mutations in a Large-Scale HIV-1 Transmitted Drug Resistance Survey in Buenos Aires, Argentina

  • Diego Cecchini,
  • Isabel Cassetti,
  • Florencia Scarnato,
  • Agustina Fiori,
  • Jimena Nuevo,
  • Clara Villaverde,
  • Adriana Sucari,
  • María C. Torroija,
  • Emiliano Bissio and
  • Gabriela Bugarin
  • + 1 author

20 May 2025

Background: Argentina has reported moderate to high levels of transmitted drug resistance in people living with HIV/AIDS (PLWHA), mostly to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Doravirine (DOR) has a unique resistance profile and...

  • Brief Report
  • Open Access
1,513 Views
9 Pages

20 May 2025

Gastroenteritis is commonly caused by viral etiologies. The inclusion of astrovirus on multiplex, syndromic gastrointestinal PCR panels allows for the detection and characterization of infected patients. This retrospective, observational, clinical st...

  • Article
  • Open Access
1 Citations
1,106 Views
14 Pages

Isolation and Pathogenicity of a Natural Recombinant Pig Reproductive and Respiratory Syndrome Virus in Northeast China

  • Zhixin Tian,
  • Qiwei Li,
  • Luxiang Xu,
  • Dexin Liang,
  • Yuan Li,
  • Ziqi Shi,
  • Lingzhi Luo,
  • Jiechao Jin,
  • Xiaoyi Huo and
  • Xiumei Dong
  • + 1 author

19 May 2025

First reported in 1987, the porcine reproductive and respiratory syndrome virus (PRRSV) has significantly disrupted the major regions affected by PRRSV in the pig breeding industry. Recently, outbreaks of disease caused by recombinant PRRSV strains i...

  • Article
  • Open Access
1,064 Views
16 Pages

19 May 2025

Infectious spleen and kidney necrosis virus (ISKNV) is an emerging viral pathogen with an expanding host range, posing a significant threat to economically important fish species. In this study, we isolated the ISKNV strain responsible for disease ou...

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Viruses - ISSN 1999-4915