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Marine Drugs, Volume 18, Issue 11

November 2020 - 61 articles

Cover Story: The extract of a Pseudosuberites sp. sponge provided three new aryl alkaloids named suberitamides A–C. Assignment of the relative configuration of the four contiguous stereogenic centers in the conformationally flexible oxolane ring in suberitamide A was accomplished using a variety of contemporary NMR techniques. These included J-based methodologies that employed new NMR experiments for the accurate determination of heteronuclear coupling constants between protons and nonprotonated carbons. The ubiquitin ligase Cbl-b is an attractive potential target for immune system modulation, and suberitamides A and B inhibited autoubiquitination of Cbl-b at low micromolar concentrations. View this paper
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Articles (61)

  • Article
  • Open Access
7 Citations
3,552 Views
15 Pages

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

  • Livan Delgado-Roche,
  • Rebeca Santes-Palacios,
  • José A. Herrera,
  • Sandra L. Hernández,
  • Mario Riera,
  • Miguel D. Fernández,
  • Fernando Mesta,
  • Gabino Garrido,
  • Idania Rodeiro and
  • Jesús Javier Espinosa-Aguirre

19 November 2020

The aim of the present work was to evaluate the effects of Thalassia testudinum hydroethanolic extract, its polyphenolic fraction and thalassiolin B on the activity of phase I metabolizing enzymes as well as their antimutagenic effects. Spectrofluoro...

  • Article
  • Open Access
27 Citations
4,855 Views
10 Pages

Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea

  • Katkam N. Gangadhar,
  • Maria João Rodrigues,
  • Hugo Pereira,
  • Helena Gaspar,
  • F. Xavier Malcata,
  • Luísa Barreira and
  • João Varela

19 November 2020

Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in...

  • Review
  • Open Access
92 Citations
10,830 Views
17 Pages

Properties of Carotenoids in Fish Fitness: A Review

  • Toshiki Nakano and
  • Geert Wiegertjes

19 November 2020

Carotenoids, one of the most common types of natural pigments, can influence the colors of living organisms. More than 750 kinds of carotenoids have been identified. Generally, carotenoids occur in organisms at low levels. However, the total amount o...

  • Review
  • Open Access
17 Citations
3,580 Views
23 Pages

19 November 2020

Natural polypropionates (PPs) are a large subgroup of polyketides with diverse structural features and bioactivities. Most of the PPs are discovered from marine organisms including mollusks, fungi and actinomycetes, while some of them are also isolat...

  • Review
  • Open Access
159 Citations
16,945 Views
31 Pages

Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties

  • Ahmed Zayed,
  • Mona El-Aasr,
  • Abdel-Rahim S. Ibrahim and
  • Roland Ulber

19 November 2020

Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within the...

  • Feature Paper
  • Review
  • Open Access
22 Citations
11,798 Views
50 Pages

19 November 2020

Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studi...

  • Article
  • Open Access
11 Citations
2,866 Views
9 Pages

Toward the Identification of Novel Antimicrobial Agents: One-Pot Synthesis of Lipophilic Conjugates of N-Alkyl d- and l-Iminosugars

  • Anna Esposito,
  • Daniele D’Alonzo,
  • Stefano D’Errico,
  • Eliana De Gregorio and
  • Annalisa Guaragna

19 November 2020

In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars 10a–b and 11a–b based on the one-pot conjugation of both enantiomeric forms of N-butyldeoxynojirimycin (NBDNJ) and N-non...

  • Article
  • Open Access
12 Citations
3,511 Views
13 Pages

Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri

  • Chia-Chi Peng,
  • Chiung-Yao Huang,
  • Atallah F. Ahmed,
  • Tsong-Long Hwang and
  • Jyh-Horng Sheu

19 November 2020

The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7). The chemical structures of 1–7 were determined by spectroscop...

  • Article
  • Open Access
16 Citations
3,973 Views
16 Pages

Temperature Differentially Affects Gene Expression in Antarctic Thraustochytrid Oblongichytrium sp. RT2316-13

  • Paris Paredes,
  • Giovanni Larama,
  • Liset Flores,
  • Allison Leyton,
  • Carmen Gloria Ili,
  • Juan A. Asenjo,
  • Yusuf Chisti and
  • Carolina Shene

18 November 2020

Oblongichytrium RT2316-13 synthesizes lipids rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The content of these fatty acids in the total lipids depended on growth temperature. Sequencing technology was used in this work to exami...

  • Review
  • Open Access
28 Citations
8,774 Views
22 Pages

Potential Anti-Aging Substances Derived from Seaweeds

  • Lei Cao,
  • Sang Gil Lee,
  • Kwon Taek Lim and
  • Hyeung-Rak Kim

18 November 2020

Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathwa...

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Mar. Drugs - ISSN 1660-3397