Special Issue "Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editor

Dr. Emiliano Manzo
E-Mail Website
Guest Editor
Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry of the National Research Council (CNR), Via Campi Flegrei 34, IT-80078 Pozzuoli, 80078 Napoli, Italy
Tel. 00390818675177
Interests: Organic Chemistry; Chemistry of Natural Products; Synthesis of Bioactive Compounds
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,                

Marine natural products are characterized by high chemical diversity, biochemical specificity and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of the isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications.
Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the way to new classes of biologically active compounds with pharmacological potential.

This Special Issue aims to collect original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that can favor applications of these molecules and/or can solve structural challenges common in the field of natural substances.

Dr. Emiliano Manzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine products
  • synthesis
  • drug discovery

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessArticle
Synthesis and Biological Evaluation of Four New Ricinoleic Acid-Derived 1-O-alkylglycerols
Mar. Drugs 2020, 18(2), 113; https://doi.org/10.3390/md18020113 (registering DOI) - 15 Feb 2020
Abstract
A series of novel substituted 1-O-alkylglycerols (AKGs) containing methoxy (8), gem-difluoro (9), azide (10) and hydroxy (11) group at 12 position in the alkyl chain were synthesized from commercially available ricinoleic acid [...] Read more.
A series of novel substituted 1-O-alkylglycerols (AKGs) containing methoxy (8), gem-difluoro (9), azide (10) and hydroxy (11) group at 12 position in the alkyl chain were synthesized from commercially available ricinoleic acid (12). The structures of these new synthesized AKGs were established by NMR experiments as well as from the HRMS and elementary analysis data. The antimicrobial activities of the studied AKGs 811 were evaluated, respectively, and all compounds exhibited antimicrobial activity to different extents alone and also when combined with some commonly used antibiotics (gentamicin, tetracycline, ciprofloxacin and ampicillin). AKG 11 was viewed as a lead compound for this series as it exhibited significantly higher antimicrobial activity than compounds 810. Full article
Show Figures

Figure 1

Open AccessArticle
In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products
Mar. Drugs 2019, 17(12), 684; https://doi.org/10.3390/md17120684 - 05 Dec 2019
Abstract
Several marine natural linear prenylquinones/hydroquinones have been identified as anticancer and antimutagenic agents. Structure-activity relationship studies on natural compounds and their synthetic analogs demonstrated that these effects depend on the length of the prenyl side chain and on the type and position of [...] Read more.
Several marine natural linear prenylquinones/hydroquinones have been identified as anticancer and antimutagenic agents. Structure-activity relationship studies on natural compounds and their synthetic analogs demonstrated that these effects depend on the length of the prenyl side chain and on the type and position of the substituent groups in the quinone moiety. Aiming to broaden the knowledge of the underlying mechanism of the antiproliferative effect of these prenylated compounds, herein we report the synthesis of two quinones 4 and 5 and of their corresponding dioxothiazine fused quinones 6 and 7 inspired to the marine natural product aplidinone A (1), a geranylquinone featuring the 1,1-dioxo-1,4-thiazine ring isolated from the ascidian Aplidium conicum. The potential effects on viability and proliferation in three different human cancer cell lines, breast adenocarcinoma (MCF-7), pancreas adenocarcinoma (Bx-PC3) and bone osteosarcoma (MG-63), were investigated. The methoxylated geranylquinone 5 exerted the highest antiproliferative effect exhibiting a comparable toxicity in all three cell lines analyzed. Interestingly, a deeper investigation has highlighted a cytostatic effect of quinone 5 referable to a G0/G1 cell-cycle arrest in BxPC-3 cells after 24 h treatment. Full article
Show Figures

Graphical abstract

Back to TopTop