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Marine Drugs, Volume 18, Issue 1

January 2020 - 69 articles

Cover Story: Natural antimicrobial peptides are considered as potential lead molecules for developing new antibiotic drugs-addressing the emerging problem of antibiotic resistance. In this study, two novel peptides, named turgencin A and turgencin B, were isolated and characterized from the Arctic colonial ascidian Synoicum turgens. The peptides are post-translationally modified, containing methionines with different degrees of oxidation, amidated C-terminus, and six cysteines with an unusual disulfide connectivity of Cys1-Cys6, Cys2-Cys5, and Cys3-Cys4. Turgencin A, with one oxidized methionine, display antimicrobial activity against both Gram-negative and Gram-positive bacteria with minimum inhibitory concentrations as low as 0.4 µM against selected bacterial strains. View this paper.
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Articles (69)

  • Article
  • Open Access
36 Citations
5,502 Views
15 Pages

Chitooligosaccharides Modulate Glucose-Lipid Metabolism by Suppressing SMYD3 Pathways and Regulating Gut Microflora

  • Qiutong Wang,
  • Yajie Jiang,
  • Xuegang Luo,
  • Chang Wang,
  • Nan Wang,
  • Hongpeng He,
  • Tongcun Zhang and
  • Liehuan Chen

20 January 2020

Chitooligosaccharides (COS) have a variety of biological activities due to their positively charged amino groups. Studies have shown that COS have antidiabetic effects, but their molecular mechanism has not been fully elucidated. The present study co...

  • Article
  • Open Access
15 Citations
4,170 Views
14 Pages

Lipoxygenase Pathways in Diatoms: Occurrence and Correlation with Grazer Toxicity in Four Benthic Species

  • Nadia Ruocco,
  • Genoveffa Nuzzo,
  • Giuliana d’Ippolito,
  • Emiliano Manzo,
  • Angela Sardo,
  • Adrianna Ianora,
  • Giovanna Romano,
  • Antonella Iuliano,
  • Valerio Zupo and
  • Maria Costantini
  • + 1 author

19 January 2020

Oxygenated derivatives of fatty acids, collectively called oxylipins, are a highly diverse family of lipoxygenase (LOX) products well described in planktonic diatoms. Here we report the first investigation of these molecules in four benthic diatoms,...

  • Article
  • Open Access
30 Citations
4,206 Views
7 Pages

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

  • Fei Zhang,
  • Liman Zhou,
  • Fandong Kong,
  • Qingyun Ma,
  • Qingyi Xie,
  • Jiuhui Li,
  • Haofu Dai,
  • Lei Guo and
  • Youxing Zhao

19 January 2020

Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haik...

  • Article
  • Open Access
56 Citations
7,075 Views
19 Pages

Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus

  • Florbela Pereira,
  • Joana R. Almeida,
  • Marisa Paulino,
  • Inês R. Grilo,
  • Helena Macedo,
  • Isabel Cunha,
  • Rita G. Sobral,
  • Vitor Vasconcelos and
  • Susana P. Gaudêncio

18 January 2020

The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and...

  • Review
  • Open Access
162 Citations
15,300 Views
23 Pages

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

  • Mitchell Jones,
  • Marina Kujundzic,
  • Sabu John and
  • Alexander Bismarck

18 January 2020

Chitin and its derivative chitosan are popular constituents in wound-treatment technologies due to their nanoscale fibrous morphology and attractive biomedical properties that accelerate healing and reduce scarring. These abundant natural polymers fo...

  • Article
  • Open Access
1 Citations
5,234 Views
12 Pages

Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening

  • Riho Kurata,
  • Kenji Shimizu,
  • Xiaofeng Cui,
  • Masamitsu Harada,
  • Takayuki Isagawa,
  • Hiroaki Semba,
  • Jun Ishihara,
  • Koji Yamada,
  • Jun Nagai and
  • Yasuhiro Yoshida
  • + 3 authors

17 January 2020

Very recently, the immunotherapies against cancer, autoimmune diseases, and infection have been feasible and promising. Thus, we have examined the possibility whether or not human gamma delta T cells can be applied for the novel immunotherapies. We p...

  • Article
  • Open Access
29 Citations
5,620 Views
20 Pages

17 January 2020

Nicotinic acetylcholine receptors (nAChRs) are membrane receptors and play a major role in tumorigenesis and cancer progression. Here, we have investigated the differential expression of nAChR subunits in human breast cancer cell lines and breast epi...

  • Article
  • Open Access
21 Citations
5,791 Views
8 Pages

Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats

  • Daniela Gabbia,
  • Miriam Saponaro,
  • Samantha Sarcognato,
  • Maria Guido,
  • Nicola Ferri,
  • Maria Carrara and
  • Sara De Martin

17 January 2020

The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. H...

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Mar. Drugs - ISSN 1660-3397