Metabolomic Approach to Investigate Marine Fungi for Drug Discovery
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (25 September 2020) | Viewed by 11747
Special Issue Editors
Interests: secondary metabolites in plant-pathogen interaction; natural substances with biological activity; chromatographic techniques; spectroscopic methods
Special Issues, Collections and Topics in MDPI journals
Interests: isolation and structure elucidation of natural compounds from microorganisms and plants; synthesis and derivatization of natural products; chromatographic techniques; analytical and spectroscopic techniques
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fungi can be thought as biosynthetic factories holding the recipes for a plethora of biologically active and structurally diverse natural products. These compounds might be valuable for drug discovery, and have potential in industrial or agricultural applications. New opportunities to identify natural fungal compounds with interesting biological activities are offered by the marine environment because of its relatively untapped biodiversity compared to terrestrial habitats.
The systematic evaluation of marine fungi and their secondary metabolites is just starting. In addition to the classic procedure of isolating and identifying bioactive fungal substances, the metabolomics approach represents an emerging tool for metabolite identification in complex samples. As a robust and comprehensive analytical method, metabolomics measures qualitative and quantitative changes of metabolites representing the functional phenotypes which are the net result of genomic, transcriptomic, and proteomic changes. This approach can also be used to optimize a biosynthetic pathway to selectively produce biologically active secondary metabolites. Furthermore, the combination of different techniques such as tandem mass spectrometry, ultraviolet, and NMR spectroscopies allows the correct identification of the basic structures of compounds in crude samples.
This Special Issue “Metabolomic Approach to Investigate Marine Fungi for Drug Discovery” is destined to gather reviews, original experimental papers, and short notes reporting findings on metabolite contents of marine fungal cultures, with metabolomic approach, for their antibiotic, antitumor, antiviral, insecticidal, antimalarial, antifouling, antioxidant, as well as other less-exploited activities.
Dr. Anna Andolfi
Dr. Marina Della Greca
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- marine-derived fungi
- metabolomics
- chemical structure elucidation
- biological activity
- mass spectrometry techniques
- liquid and gas chromatography
- NMR
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