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Shellmycin A–D, Novel Bioactive Tetrahydroanthra-γ-Pyrone Antibiotics from Marine Streptomyces sp. Shell-016

by Yong Han 1,2,*, Yan Wang 3, Yuehan Yang 2 and Haotong Chen 2,*
1
School of Basic Medical Science, Shandong University, Jinan 250012, China
2
Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
3
Collage of marine life science, Ocean University of China, Qingdao 266003, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 58; https://doi.org/10.3390/md18010058
Received: 18 December 2019 / Revised: 7 January 2020 / Accepted: 12 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Products from Marine Actinomycetes)
Four novel bioactive tetrahydroanthra-γ-pyrone compounds, shellmycin A–D (14), were isolated from the marine Streptomyces sp. shell-016 derived from a shell sediment sample collected from Binzhou Shell Dike Island and Wetland National Nature Reserve, China. The structures of these four compounds were established by interpretation of 1D and 2D NMR and HR-MS data, in which the absolute configuration of 1 was confirmed by single crystal X-ray diffraction, and compound 3 and 4 are a pair of stereoisomers. Compound 14 exhibited cytotoxic activity against five cancer cell lines with the IC50 value from 0.69 μM to 26.3 μM. Based on their structure–activity relationship, the putative biosynthetic pathways of these four compounds were also discussed. View Full-Text
Keywords: marine Streptomyces sp.; shell-016; tetrahydroanthra-γ-pyrone; NMR and single crystal X-ray diffraction; stereoisomers; cytotoxic activity marine Streptomyces sp.; shell-016; tetrahydroanthra-γ-pyrone; NMR and single crystal X-ray diffraction; stereoisomers; cytotoxic activity
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MDPI and ACS Style

Han, Y.; Wang, Y.; Yang, Y.; Chen, H. Shellmycin A–D, Novel Bioactive Tetrahydroanthra-γ-Pyrone Antibiotics from Marine Streptomyces sp. Shell-016. Mar. Drugs 2020, 18, 58.

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