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XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products
Open AccessReview

Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review

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Department of Pharmacognosy and Medicinal plants, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt
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Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
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Center of Drug Discovery Research and Development, Ain-Shams University, Cairo 11566, Egypt
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Plant General Manager and Technical Director, Mepaco Co., Sharkeiya 11361, Egypt
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Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 41; https://doi.org/10.3390/md18010041
Received: 11 December 2019 / Revised: 27 December 2019 / Accepted: 3 January 2020 / Published: 6 January 2020
One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus Sacrophyton. The total number of species belonging to it was estimated to be 40. Sarcophyton species are considered to be a reservoir of bioactive natural metabolites. Secondary metabolites isolated from members belonging to this genus show great chemical diversity. They are rich in terpenoids, in particular, cembranoids diterpenes, tetratepenoids, triterpenoids, and ceramide, in addition to steroids, sesquiterpenes, and fatty acids. They showed a broad range of potent biological activities, such as antitumor, neuroprotective, antimicrobial, antiviral, antidiabetic, antifouling, and anti-inflammatory activity. This review presents all isolated secondary metabolites from species of genera Sacrophyton, as well as their reported biological activities covering a period of about two decades (1998–2019). It deals with 481 metabolites, including 323 diterpenes, 39 biscembranoids, 11 sesquiterpenes, 53 polyoxygenated sterols, and 55 miscellaneous and their pharmacological activities. View Full-Text
Keywords: Sacrphyton; soft coral; terpenoids; antimicrobial; antitumor; antidiabetic; anti-inflammatory Sacrphyton; soft coral; terpenoids; antimicrobial; antitumor; antidiabetic; anti-inflammatory
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Elkhawas, Y.A.; Elissawy, A.M.; Elnaggar, M.S.; Mostafa, N.M.; Al-Sayed, E.; Bishr, M.M.; Singab, A.N.B.; Salama, O.M. Chemical Diversity in Species Belonging to Soft Coral Genus Sacrophyton and Its Impact on Biological Activity: A Review. Mar. Drugs 2020, 18, 41.

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