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Mar. Drugs, Volume 17, Issue 12 (December 2019) – 62 articles
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Cover Story (view full-size image) Meroterpenes, prenylated quinones/hydroquinones commonly found in marine organisms, stand out for [...] Read more. Meroterpenes, prenylated quinones/hydroquinones commonly found in marine organisms, stand out for their potential as anticancer agents. SAR studies on both natural and synthetic meroterpenes with linear isoprenoid chains linked at quinone ring evidenced that their bioactivity is strongly affected by the nature and position of the quinone substituents and by the prenyl group length. On this basis, we synthesized several quinones and thiazinoquinones inspired to the pro-apoptotic natural geranylthiazinoquinone aplidinone A, isolated from the marine ascidian A. conicum. The effect of these molecules on viability and proliferation of different human cancer cells was investigated; one of the tested compounds exerted significant antiproliferative activity and a cytostatic effect referable to a G0/G1 cell-cycle arrest in BxPC-3 cells after 24 h treatment. View this paper.