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Marine Drugs, Volume 17, Issue 12

December 2019 - 62 articles

Cover Story: Meroterpenes, prenylated quinones/hydroquinones commonly found in marine organisms, stand out for their potential as anticancer agents. SAR studies on both natural and synthetic meroterpenes with linear isoprenoid chains linked at quinone ring evidenced that their bioactivity is strongly affected by the nature and position of the quinone substituents and by the prenyl group length. On this basis, we synthesized several quinones and thiazinoquinones inspired to the pro-apoptotic natural geranylthiazinoquinone aplidinone A, isolated from the marine ascidian A. conicum. The effect of these molecules on viability and proliferation of different human cancer cells was investigated; one of the tested compounds exerted significant antiproliferative activity and a cytostatic effect referable to a G0/G1 cell-cycle arrest in BxPC-3 cells after 24 h treatment. View this paper.
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Articles (62)

  • Article
  • Open Access
29 Citations
3,890 Views
9 Pages

Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus Daldinia eschscholtzii HJ004

  • Hai-Xia Liao,
  • Tai-Ming Shao,
  • Rong-Qing Mei,
  • Guo-Lei Huang,
  • Xue-Ming Zhou,
  • Cai-Juan Zheng and
  • Chang-Yun Wang

17 December 2019

Two new polyketides, 8-O-methylnodulisporin F (1) and nodulisporin H (2), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone (3) and 5-hydroxy-2-methoxynaphtho[9–c]furan-1,4-dione (4), and a new naphthofuran 1,3,8-trim...

  • Article
  • Open Access
12 Citations
3,472 Views
10 Pages

Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis

  • Carolina Rodrigues Felix,
  • Jill C. Roberts,
  • Priscilla L. Winder,
  • Rashmi Gupta,
  • M. Cristina Diaz,
  • Shirley A. Pomponi,
  • Amy E. Wright and
  • Kyle H. Rohde

16 December 2019

Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge...

  • Article
  • Open Access
26 Citations
6,168 Views
15 Pages

16 December 2019

The structure of pepsin-solubilized collagen (PSC) obtained from the skin of Lophius litulon was analyzed using the sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE), Fourier transform infrared spectroscopy (FTIR), and scanning ele...

  • Article
  • Open Access
7 Citations
3,574 Views
12 Pages

16 December 2019

Siderophores are iron chelators with low molecular weight secreted by microorganisms. Siderophores have the potential to become natural iron fortifiers. To explore the feasibility of the application of Synechococcus sp. PCC7002-derived siderophores a...

  • Article
  • Open Access
9 Citations
3,090 Views
9 Pages

Fragilides U–W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis

  • Tung-Pin Su,
  • Chien-Han Yuan,
  • Yi-Ming Jhu,
  • Bo-Rong Peng,
  • Zhi-Hong Wen,
  • Yu-Jen Wu,
  • Tung-Ying Wu,
  • Hong-Wen Liu and
  • Ping-Jyun Sung

15 December 2019

Three new 11,20-epoxybriaranes—fragilides U–W (1–3), as well as two known metabolites, junceellonoid D (4) and junceellin (5), were obtained from the octocoral Junceella fragilis. The structures of briaranes 1–3 were elucidate...

  • Article
  • Open Access
19 Citations
3,884 Views
10 Pages

14 December 2019

Our purpose was to characterize the structures of deinoxanthin from Deinococcus sp. AJ005. The latter is a novel reddish strain and was found to synthesize two main acyclic carotenoids: deinoxanthin and its derivative. The derivative (2-keto-deinoxan...

  • Article
  • Open Access
27 Citations
4,140 Views
19 Pages

Isolation, Optimization of Fermentation Conditions, and Characterization of an Exopolysaccharide from Pseudoalteromonas agarivorans Hao 2018

  • Lujiang Hao,
  • Wenlin Liu,
  • Kai Liu,
  • Kai Shan,
  • Chunlei Wang,
  • Chenxiang Xi,
  • Jianbang Liu,
  • Qiuping Fan,
  • Xiaofei Zhang and
  • Xiaoping Lu
  • + 5 authors

13 December 2019

In recent years, the wide application of exopolysaccharides (EPSs) in food, cosmetics, medicine, and other fields has drawn tremendous attention. In this study, an EPS produced by Pseudoalteromonas agarivorans Hao 2018 was isolated and purified, and...

  • Article
  • Open Access
21 Citations
4,491 Views
6 Pages

Stable Tetrodotoxin Production by Bacillus sp. Strain 1839

  • Daria I. Melnikova,
  • Anna E. Vlasenko and
  • Timur Yu. Magarlamov

13 December 2019

For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host. A reliable method suitable for bacterial samples, high-performance liquid chr...

  • Article
  • Open Access
16 Citations
4,547 Views
14 Pages

12 December 2019

Haematococcus pluvialis is widely distributed in the world and well known as the richest natural source of astaxanthin that is a strong antioxidant with excellent commercial value. The pathway of astaxanthin biosynthesis in H. pluvialis has been docu...

  • Article
  • Open Access
13 Citations
3,523 Views
9 Pages

Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium Enhygromyxa sp.

  • Fan Zhang,
  • Doug R. Braun,
  • Scott R. Rajski,
  • Don DeMaria and
  • Tim S. Bugni

12 December 2019

To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing sour...

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Mar. Drugs - ISSN 1660-3397