Mar. Drugs, Volume 18, Issue 2 (February 2020) – 61 articles
Cover Story (view full-size image): Microbial co-cultivation is known to trigger silent biosynthetic gene clusters (BGC) for upregulation of known compounds and/or producing new metabolites, but the selection of appropriate microbial partners is challenging. Based on their anti‐phytopathogenic potency, eight marine sediment‐derived fungi were classified as strong or weak and co-cultured systematically. Co‐cultivation of two fungi Plenodomus influorescens (strong) and Pyrenochaeta nobilis (weak) resulted in the characterization of a new macrolide dendrodolide N and a new azaphilone 8a-hydroxy-spiciferinone. The known metabolite bis‐naphtho‐γ‐pyrone cephalochromin was specifically enhanced in the co-culture, exhibiting the strongest anti‐phytopathogenic activity against Xanthomonas campestris with IC50 value of 0.9 µg/mL. View this paper.
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