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Article

Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats

1
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35100 Padova, Italy
2
Department of Medicine, University of Padova, 35100 Padova, Italy
3
Venetian Institute of Molecular Medicine—VIMM, 35100 Padova, Italy
4
Department of Medicine, General Pathology and Cytophatology Unit, University of Padova, 35100 Padova, Italy
5
Department of Pathology, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, Italy
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 62; https://doi.org/10.3390/md18010062
Received: 20 December 2019 / Revised: 11 January 2020 / Accepted: 13 January 2020 / Published: 17 January 2020
(This article belongs to the Collection Marine Drugs in the Management of Metabolic Diseases)
The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted from these seaweeds on the deposition of fat in the liver after the administration of a high-fat diet (HFD) to rats for five weeks. The administration of F. vesiculosus and A. nodosum led to significant reductions in microvescicular steatosis and plasma biochemical and lipid parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total and conjugated bilirubin, and triglycerides. Furthermore, the postprandial glycemic peak was delayed and significantly reduced (p < 0.01) by the algal extract administration. In conclusion, this extract is effective in reducing microvescicular steatosis and improving glycemic control, thereby lowering the risk of nonalcoholic fatty liver disease, obesity, and diabetes, diseases related to the consumption of fat and sugar-enriched diets. View Full-Text
Keywords: Fucus vesiculosus; Ascophyllum nodosum; brown seaweeds; NAFLD; insulin resistance; blood glucose Fucus vesiculosus; Ascophyllum nodosum; brown seaweeds; NAFLD; insulin resistance; blood glucose
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MDPI and ACS Style

Gabbia, D.; Saponaro, M.; Sarcognato, S.; Guido, M.; Ferri, N.; Carrara, M.; De Martin, S. Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats. Mar. Drugs 2020, 18, 62. https://doi.org/10.3390/md18010062

AMA Style

Gabbia D, Saponaro M, Sarcognato S, Guido M, Ferri N, Carrara M, De Martin S. Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats. Marine Drugs. 2020; 18(1):62. https://doi.org/10.3390/md18010062

Chicago/Turabian Style

Gabbia, Daniela, Miriam Saponaro, Samantha Sarcognato, Maria Guido, Nicola Ferri, Maria Carrara, and Sara De Martin. 2020. "Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats" Marine Drugs 18, no. 1: 62. https://doi.org/10.3390/md18010062

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