Marine Drugs Acting as Autophagy Modulators
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 9475
Special Issue Editors
Interests: medical oncology; drug resistance; marine anti-cancer compounds; drug development; tumor biology; proteomics
Special Issues, Collections and Topics in MDPI journals
2. Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Interests: marine natural compounds; secondary metabolites; anticancer activity; mechanism of action; autophagy; drug combinational studies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Compared to terrestrial life forms, marine inhabitants are by far less well studied organisms. At the same time, due to the special and often extreme environmental conditions they live in (high pressure, lack of light, salinity, pH), they harbor a unique variety of chemical compounds, and there are probably still many more to be discovered. A good proportion of these compounds exhibit potent biological activity, targeting one or several specific biological processes.
Autophagy is one of these processes, which has only recently received more attention. This cellular process, which is implicated in many aspects of human physiology and disease, including cancer, neurodegenerative conditions (Parkinson's and Alzheimer's disease), cardiomyopathy, and others, is essential for the survival and death of mammalian cells. It is an exciting perspective to find and develop compounds that have the ability to control and manipulate this process.
This Special Issue “Marine Drugs acting as Autophagy Modulators” of Marine Drugs will cover the whole scope from agents with autophagy-modulating activity, both novel to previously characterized, including already clinically used marine-derived compounds known to have the ability to modulate autophagy both in vitro and in vivo. The issue will present work on compounds that are able to modulate all the different types of autophagy—i.e., macroautophagy, microautophagy, and chaperone-mediated autophagy—with cytotoxic, cytoprotective, pro-survival, or noncytotoxic biological activity.
Since autophagy is a relatively new and sometimes still controversial topic, results of similar experiments are often interpreted in different ways. Therefore, for interpretation of experimental data submitted to this Special Issue, the guest editors suggest using the recommendations published by Klionsky et al. in the “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)” (Autophagy. 2016;12(1):1-222; PMID: 26799652) as well as by Yoshii and Mizushima “Monitoring and Measuring Autophagy” (Int J Mol Sci. 2017;18(9):1865; PMID: 28846632)
Dr. Friedemann Honecker
Dr. Sergey A. Dyshlovoy
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
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