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Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona
Open AccessReview

Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species

Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Key Laboratory of marine biotechnology in Universities of Shandong (Ludong University), School of Life Sciences, Ludong University, Yantai 264025, China
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 54;
Received: 27 December 2019 / Revised: 10 January 2020 / Accepted: 11 January 2020 / Published: 14 January 2020
(This article belongs to the Special Issue Advances in Marine Alkaloids)
Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of the most well-known universal groups of filamentous fungi, marine-derived Aspergillus species produce a large number of structurally unique heterocyclic alkaloids. This review attempts to provide a comprehensive summary of the structural diversity and biological activities of heterocyclic alkaloids that are produced by marine-derived Aspergillus species. Herein, a total of 130 such structures that were reported from the beginning of 2014 through the end of 2018 are included, and 75 references are cited in this review, which will benefit future drug development and innovation.
Keywords: Aspergillus; metabolite; marine; alkaloid; biological activity Aspergillus; metabolite; marine; alkaloid; biological activity
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Xu, K.; Yuan, X.-L.; Li, C.; Li, A.-D. Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species. Mar. Drugs 2020, 18, 54.

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