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XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products
Open AccessArticle

Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus

1
LAQV, Chemistry Department, Faculty for Sciences and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal
2
CIIMAR/CIMAR—Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, 4450-208 Matosinhos, Portugal
3
UCIBIO, Chemistry Department, Blue Biotechnology and Biomedicine Lab, Faculty for Sciences and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal
4
UCIBIO, Life Sciences Department, MOLMICRO of Bacterial Pathogens Lab, Faculty for Sciences and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal
5
Biology Department, Faculty of Sciences, Porto University, Rua do Campo Alegre, 4069-007 Porto, Portugal
*
Author to whom correspondence should be addressed.
Dedicated to the memory of our friend and colleague Ilda Santos-Sanches.
Mar. Drugs 2020, 18(1), 63; https://doi.org/10.3390/md18010063
Received: 6 December 2019 / Revised: 14 January 2020 / Accepted: 16 January 2020 / Published: 18 January 2020
(This article belongs to the Special Issue Selected Papers from XVI MaNaPro and XI ECMNP)
The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products. View Full-Text
Keywords: marine natural products; actinomycetes; biofouling; antifouling; antibiofilm; napyradiomycins; meroterpenoids; hybrid isoprenoids; drug discovery; bioprospection marine natural products; actinomycetes; biofouling; antifouling; antibiofilm; napyradiomycins; meroterpenoids; hybrid isoprenoids; drug discovery; bioprospection
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Pereira, F.; Almeida, J.R.; Paulino, M.; Grilo, I.R.; Macedo, H.; Cunha, I.; Sobral, R.G.; Vasconcelos, V.; Gaudêncio, S.P. Antifouling Napyradiomycins from Marine-Derived Actinomycetes Streptomyces aculeolatus. Mar. Drugs 2020, 18, 63.

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