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Open AccessArticle

Stable Tetrodotoxin Production by Bacillus sp. Strain 1839

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia
School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, Russia
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 704;
Received: 29 October 2019 / Revised: 11 December 2019 / Accepted: 12 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection)
For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host. A reliable method suitable for bacterial samples, high-performance liquid chromatography with tandem mass spectrometry, was used for toxin detection in spore and vegetative cultures of Bacillus sp. 1839. TTX was detected in a spore culture of the strain. View Full-Text
Keywords: tetrodotoxin; TTX; Bacillus; spores; TTX-producing bacteria; HPLC-MS/MS tetrodotoxin; TTX; Bacillus; spores; TTX-producing bacteria; HPLC-MS/MS
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Melnikova, D.I.; Vlasenko, A.E.; Magarlamov, T.Y. Stable Tetrodotoxin Production by Bacillus sp. Strain 1839. Mar. Drugs 2019, 17, 704.

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