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Open AccessArticle

Stable Tetrodotoxin Production by Bacillus sp. Strain 1839

1
A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia
2
School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, Russia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 704; https://doi.org/10.3390/md17120704
Received: 29 October 2019 / Revised: 11 December 2019 / Accepted: 12 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection)
For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host. A reliable method suitable for bacterial samples, high-performance liquid chromatography with tandem mass spectrometry, was used for toxin detection in spore and vegetative cultures of Bacillus sp. 1839. TTX was detected in a spore culture of the strain. View Full-Text
Keywords: tetrodotoxin; TTX; Bacillus; spores; TTX-producing bacteria; HPLC-MS/MS tetrodotoxin; TTX; Bacillus; spores; TTX-producing bacteria; HPLC-MS/MS
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Melnikova, D.I.; Vlasenko, A.E.; Magarlamov, T.Y. Stable Tetrodotoxin Production by Bacillus sp. Strain 1839. Mar. Drugs 2019, 17, 704.

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