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Open AccessArticle

Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium Enhygromyxa sp.

Pharmaceutical Sciences Division, University of Wisconsin–Madison, Madison, WI 53705, USA
Sea Samples, 369 Westshore Drive, Summerland Key, FL 33042, USA
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 698;
Received: 20 November 2019 / Revised: 6 December 2019 / Accepted: 10 December 2019 / Published: 12 December 2019
To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wide array of biological activities. Marine-derived myxobacteria are especially attractive due to their unique biosynthetic gene clusters, although they are more difficult to handle than terrestrial myxobacteria. Here, we report the discovery of two new pyrazinone-type molecules, enhypyrazinones A and B, from a marine-derived myxobacterium Enhygromyxa sp. Their structures were elucidated by HRESIMS and comprehensive NMR data analyses. Compounds 1 and 2, which contain a rare trisubstituted-pyrazinone core, represent a unique class of molecules from Enhygromyxa sp. View Full-Text
Keywords: pyrazinone; marine-derived myxobacterium; Enhygromyxa sp. pyrazinone; marine-derived myxobacterium; Enhygromyxa sp.
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Zhang, F.; Braun, D.R.; Rajski, S.R.; DeMaria, D.; Bugni, T.S. Enhypyrazinones A and B, Pyrazinone Natural Products from a Marine-Derived Myxobacterium Enhygromyxa sp.. Mar. Drugs 2019, 17, 698.

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