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Open AccessArticle

Effect of Oral Administration of Active Peptides of Pinctada Martensii on the Repair of Skin Wounds

by Faming Yang 1, Xiaoming Qin 1,2,3,4,5,6,*, Ting Zhang 1, Chaohua Zhang 1,2,3,4,5,6 and Haisheng Lin 1,2,3,4,5,6
1
College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
2
National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Zhanjiang 524088, China
3
Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Zhanjiang 524088, China
4
Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, China
5
Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China
6
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Zhanjiang 524088, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 697; https://doi.org/10.3390/md17120697
Received: 21 November 2019 / Revised: 5 December 2019 / Accepted: 10 December 2019 / Published: 12 December 2019
Skin wound healing, especially chronic wound healing, is a common challenging clinical problem. It is urgent to broaden the sources of bioactive substances that can safely and efficiently promote skin wound healing. This study aimed to observe the effects of active peptides (APs) of the mantle of Pinctada martensii on wound healing. After physicochemical analysis of amino acids and mass spectrometry of APs, the effect of APs on promoting healing was studied through a whole cortex wound model on the back of mice for 18 consecutive days. The results showed that APs consisted of polypeptides with molecular weights in the range 302.17–2936.43 Da. The content of polypeptides containing 2–15 amino acids accounted for 73.87%, and the hydrophobic amino acids accounted for 56.51%. Results of in vitro experimentation showed that mice in APs-L group which were fed a low dose of APs (0.5 g/kg bw) had a shortened epithelialization time due to a shortening inflammatory period (p < 0.05). Mechanistically, this relied on its specific ability to promote the proliferation of CD31, FGF and EGF which accelerated the percentage of wound closure. Moreover, the APs-L group mice had enhanced collagen synthesis and increased type III collagen content in their wounds through a TGF-β/Smad signaling pathway (p > 0.05). Consequently, scar formation was inhibited and wound healing efficiency was significantly improved. These results show that the APs of Pinctada martensii promote dermal wound healing in mice and have tremendous potential for development and utilization in skin wound healing. View Full-Text
Keywords: Pinctada martensii; mantle; active peptides; skin; wound healing Pinctada martensii; mantle; active peptides; skin; wound healing
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Yang, F.; Qin, X.; Zhang, T.; Zhang, C.; Lin, H. Effect of Oral Administration of Active Peptides of Pinctada Martensii on the Repair of Skin Wounds. Mar. Drugs 2019, 17, 697.

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