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Open AccessArticle

Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli

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College of Food and Biological Engineering, Jimei University, Xiamen 361021, China
2
Xiamen Key Laboratory of Marine Functional Food, Xiamen 361021, China
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School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 694; https://doi.org/10.3390/md17120694
Received: 3 November 2019 / Revised: 3 December 2019 / Accepted: 7 December 2019 / Published: 10 December 2019
Active polysaccharides as safe and natural polymers against bacterial diarrhea have been reconsidered as an alternative to antibiotics. This work investigated the inhibiting effect of depolymerized sulfated galactans from Eucheuma serra and Gracilaria verrucosa on the growth and adhesion of diarrheagenic enterotoxigenic Escherichia coli (ETEC) K88. Results showed that the sulfated polysaccharides with molecular weight distribution ≤20.0 kDa exhibited antibacterial activity against ETEC K88. A structure–activity study revealed that the anti-ETEC K88 activity of sulfated polysaccharides is strictly determined by their molecular weight distribution, sulfate group content, and monosaccharide composition. In addition, the promoted nucleic acid release and the fluorescence quenching of membrane proteins were observed after the treatment with selected polysaccharides. Scanning electron microscopy further confirmed that the depolymerized sulfated galactans can effectively inhibit ETEC K88 adhesion. In conclusion, depolymerized sulfated galactans exhibited an inhibitory effect on the growth and adhesion of ETEC K88. View Full-Text
Keywords: sulfated galactans; marine algae; enterotoxigenic Escherichia coli; anti-diarrhea; anti-adhesion sulfated galactans; marine algae; enterotoxigenic Escherichia coli; anti-diarrhea; anti-adhesion
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Liu, Y.; Liu, W.; Wang, Y.; Ma, Y.; Huang, L.; Zou, C.; Li, D.; Cao, M.-J.; Liu, G.-M. Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli. Mar. Drugs 2019, 17, 694.

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