Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus Daldinia eschscholtzii HJ004
by
Hai-Xia Liao 1,2,3,4, Tai-Ming Shao 4, Rong-Qing Mei 1,2, Guo-Lei Huang 1,2, Xue-Ming Zhou 1,2, Cai-Juan Zheng 1,2,* and Chang-Yun Wang 3,*
Hai-Xia Liao 1,2,3,4, Tai-Ming Shao 4, Rong-Qing Mei 1,2, Guo-Lei Huang 1,2, Xue-Ming Zhou 1,2, Cai-Juan Zheng 1,2,* and Chang-Yun Wang 3,*
1
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
2
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
3
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
4
Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin 537000, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 710; https://doi.org/10.3390/md17120710
Received: 9 October 2019 / Revised: 2 December 2019 / Accepted: 11 December 2019 / Published: 17 December 2019
Two new polyketides, 8-O-methylnodulisporin F (1) and nodulisporin H (2), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone (3) and 5-hydroxy-2-methoxynaphtho[9–c]furan-1,4-dione (4), and a new naphthofuran 1,3,8-trimethoxynaphtho[9–c]furan (5), along with five known compounds 4-O-methyl eleutherol (6), 2-acetyl-7-methoxybenzofuran (7), (-)-orthosporin (8), diaporthin (9), and 6-hydroxymellein (10), were obtained from the EtOAc extract of the mangrove-derived fungus Daldinia eschscholtzii HJ004. The structures of the isolated compounds were elucidated by extensive NMR and MS analyses, while the absolute configurations of the stereogenic carbons were established based on experimental and calculated electronic circular dichroism spectra. Compounds 4 and 7 displayed a potent inhibitory activity against α-glucosidase with the IC50 values of 5.7 and 1.1 μg/mL, respectively. Compounds 1 and 2 showed a moderate antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA) and Bacillus cereus, with minimum inhibitory concentration (MIC) values ranging from 6.25 to 12.5 μg/mL. Compound 3 exhibited antibacterial activity against B. cereus with the MIC value of 12.5 μg/mL.
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Keywords:
Daldinia eschscholtzii; polyketides; naphthoquinones; antibacterial activity; α-glucosidase inhibitory activity
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MDPI and ACS Style
Liao, H.-X.; Shao, T.-M.; Mei, R.-Q.; Huang, G.-L.; Zhou, X.-M.; Zheng, C.-J.; Wang, C.-Y. Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus Daldinia eschscholtzii HJ004. Mar. Drugs 2019, 17, 710.
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