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Open AccessArticle

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

1
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, Poland
2
Institute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 692; https://doi.org/10.3390/md17120692
Received: 30 October 2019 / Revised: 26 November 2019 / Accepted: 7 December 2019 / Published: 9 December 2019
(This article belongs to the Special Issue Marine Polysaccharides in Pharmaceutical Applications)
Sodium alginate and its oligosaccharides through potential antifungal properties might improve the activity of antifungal drugs enhancing their efficacy and potentially reducing the frequency of application. Mucoadhesive buccal films are oral dosage forms designed for maintaining both local or systemic drug effects and seem to be a very promising alternative to conventional oral formulations. Hence, in this study, mucoadhesive buccal films based on the alginate and its oligosaccharide oligomer composed predominantly of mannuronic acid for the administration of posaconazole-antifungal drug from the azole group were developed. As the polymer gelation method, a relatively new freeze-thaw technique was chosen. All prepared formulations were examined for pharmaceutical tests, swelling, mechanical, and mucoadhesive properties. In addition, the influence of sodium alginate (ALG) and alginate oligosaccharides (OLG) on POS antifungal activity on Candida species was performed. It was observed that film formulation containing 1% ALG and 1% OLG (F2) was characterized by optimal mucoadhesive and swelling properties and prolonged drug release up to 5 h. Additionally, it was shown that OLG affected the growth reduction of all tested Candida spp. The obtained data has opened the way for future research for developing OLG-based dosage forms, which might increase the activity of antifungal drugs. View Full-Text
Keywords: alginate; alginate oligosaccharides; posaconazole; buccal films; antifungal activity; freeze-thaw technique alginate; alginate oligosaccharides; posaconazole; buccal films; antifungal activity; freeze-thaw technique
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MDPI and ACS Style

Szekalska, M.; Wróblewska, M.; Trofimiuk, M.; Basa, A.; Winnicka, K. Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole. Mar. Drugs 2019, 17, 692.

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