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Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
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Mar. Drugs 2019, 17(12), 682; https://doi.org/10.3390/md17120682
Received: 12 November 2019 / Revised: 26 November 2019 / Accepted: 2 December 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Advances in Marine Alkaloids)
Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metabolites from classified and unclassified Haliclona sponges as well as from their symbiotic microorganisms. Most of these substances have only been found in Haliclona sponges, and display diverse bioactive properties with potential applications in new drug discovery. View Full-Text
Keywords: marine sponge; Haliclona; symbiotic microbe; secondary metabolite; alkaloid; bioactivity marine sponge; Haliclona; symbiotic microbe; secondary metabolite; alkaloid; bioactivity
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MDPI and ACS Style

Zhu, J.; Liu, Y.; Liu, Z.; Wang, H.; Zhang, H. Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona. Mar. Drugs 2019, 17, 682.

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