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Open AccessArticle

Fragilides U–W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Department of Otolaryngology, Kaohsiung Armed General Hospital, Kaohsiung 802, Taiwan
4
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Department of Nursing, Meiho University, Pingtung 912, Taiwan
6
Department of Biological Science & Technology, Meiho University, Pingtung 912, Taiwan
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Department of Food Science and Nutrition, Meiho University, Pingtung 912, Taiwan
8
Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan
9
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(12), 706; https://doi.org/10.3390/md17120706
Received: 16 November 2019 / Revised: 11 December 2019 / Accepted: 13 December 2019 / Published: 15 December 2019
(This article belongs to the Special Issue Bioactive Compounds from Coral Reef Organisms)
Three new 11,20-epoxybriaranes—fragilides U–W (13), as well as two known metabolites, junceellonoid D (4) and junceellin (5), were obtained from the octocoral Junceella fragilis. The structures of briaranes 13 were elucidated by spectroscopic methods and briaranes 3 and 5 displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7. View Full-Text
Keywords: Junceella fragilis; fragilide; briarane; gorgonian; junceellonoid; junceellin; iNOS Junceella fragilis; fragilide; briarane; gorgonian; junceellonoid; junceellin; iNOS
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MDPI and ACS Style

Su, T.-P.; Yuan, C.-H.; Jhu, Y.-M.; Peng, B.-R.; Wen, Z.-H.; Wu, Y.-J.; Wu, T.-Y.; Liu, H.-W.; Sung, P.-J. Fragilides U–W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis. Mar. Drugs 2019, 17, 706.

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