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Marine Drugs, Volume 16, Issue 1

January 2018 - 38 articles

Cover Story: Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and subtropical oceans. Aaptamine, demethyloxyaaptamine, and isoaaptamine were isolated from Aaptos sp. methanolic extract. In this study, we sought to elucidate the cytotoxic activity of aaptamine alkaloids in vitro along with their mechanism of action. The effect of IAp treatment on ROS generation and ER stress-related proteins in breast T-47D cancer cells was evaluated showing an enhancement in ROS generation as well as IRE 1α and Bip expression. Based on the results that ROS and ER stress are involved in IAp effect on T-47D cells, we hypothesized that the induction of apoptosis and autophagy might be attributed to mitochondrial dysfunction-dependent apoptosis and Nrf2/p62 dependent autophagy.
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Articles (38)

  • Article
  • Open Access
31 Citations
6,489 Views
15 Pages

Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria

  • Jingyuan Sun,
  • Jiru Wu,
  • Bang An,
  • Nicole J. de Voogd,
  • Wei Cheng and
  • Wenhan Lin

2 January 2018

Anti-biofilm assay guided fractionation of the marine sponge Stylissa massa revealed the butanol soluble fraction that was possessing the inhibitory activity toward the biofilm formation of bacterium E. coli. Chromatographic separation of the bioacti...

  • Article
  • Open Access
55 Citations
10,197 Views
19 Pages

MSP-4, an Antimicrobial Peptide, Induces Apoptosis via Activation of Extrinsic Fas/FasL- and Intrinsic Mitochondria-Mediated Pathways in One Osteosarcoma Cell Line

  • Hsiao-Mei Kuo,
  • Chung-Chih Tseng,
  • Nan-Fu Chen,
  • Ming-Hong Tai,
  • Han-Chun Hung,
  • Chien-Wei Feng,
  • Shu-Yu Cheng,
  • Shi-Ying Huang,
  • Yen-Hsuan Jean and
  • Zhi-Hong Wen

2 January 2018

Osteosarcoma (OS) is a common malignant bone cancer. The relatively high density of a person’s bone structure means low permeability for drugs, and so finding drugs that can be more effective is important and should not be delayed. MSPs are marine an...

  • Review
  • Open Access
16 Citations
7,955 Views
32 Pages

Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products

  • Pablo A. García,
  • Elena Valles,
  • David Díez and
  • María-Ángeles Castro

1 January 2018

Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source...

  • Article
  • Open Access
50 Citations
8,381 Views
19 Pages

Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters

  • Michaela E. Larsson,
  • Olivier F. Laczka,
  • D. Tim Harwood,
  • Richard J. Lewis,
  • S. W. A. Himaya,
  • Shauna A. Murray and
  • Martina A. Doblin

1 January 2018

Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus Gambierdiscus. Here, we describe...

  • Article
  • Open Access
8 Citations
5,849 Views
13 Pages

Pinnatifidenyne-Derived Ethynyl Oxirane Acetogenins from Laurencia viridis

  • Adrián Morales-Amador,
  • Caterina R. De Vera,
  • Olivia Márquez-Fernández,
  • Antonio Hernández Daranas,
  • José M. Padrón,
  • José J. Fernández,
  • María L. Souto and
  • Manuel Norte

29 December 2017

Red algae of Laurencia continue to provide wide structural diversity and complexity of halogenated C15 acetogenin medium-ring ethers. Here, we described the isolation of three new C15 acetogenins (3–5), and one truncated derivative (6) from Laurencia...

  • Article
  • Open Access
12 Citations
4,630 Views
12 Pages

Characterization of a Long-Lived Alginate Lyase Derived from Shewanella Species YH1

  • Hisashi Yagi,
  • Natsuki Isobe,
  • Narumi Itabashi,
  • Asako Fujise and
  • Takashi Ohshiro

27 December 2017

Polysaccharides from seaweeds are widely used in various fields, including the food, biomedical material, cosmetic, and biofuel industries. Alginate, which is a major polysaccharide in brown algae, and the products of its degradation (oligosaccharide...

  • Article
  • Open Access
109 Citations
9,007 Views
11 Pages

Marine Cryptophytes Are Great Sources of EPA and DHA

  • Elina Peltomaa,
  • Matthew D. Johnson and
  • Sami J. Taipale

26 December 2017

Microalgae have the ability to synthetize many compounds, some of which have been recognized as a source of functional ingredients for nutraceuticals with positive health effects. One well-known example is the long-chain polyunsaturated fatty acids (...

  • Article
  • Open Access
19 Citations
6,581 Views
19 Pages

Topical Application of Glycolipids from Isochrysis galbana Prevents Epidermal Hyperplasia in Mice

  • Azahara Rodríguez-Luna,
  • Elena Talero,
  • María Del Carmen Terencio,
  • María Luisa González-Rodríguez,
  • Antonio M. Rabasco,
  • Carolina De los Reyes,
  • Virginia Motilva and
  • Javier Ávila-Román

25 December 2017

Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-ac...

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Mar. Drugs - ISSN 1660-3397