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Special Issue "Bioactive Compounds from Mangroves and Their-Associated Microbes"

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: 31 January 2019

Special Issue Editor

Guest Editor
Prof. Dr. Hee Jae Shin

Korea Institute of Ocean Science and Technology, Marine Natural Products Laboratory, 787 Haeanro, Ansan 426-744, Korea
E-Mail
Interests: isolation and characterization of marine natural products; drug discovery; anti-cancer compounds; anti-inflammatory compounds, anti-microbial compounds

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to demonstrate the importance of some mangroves and mangrove-derived microbes as a source of novel compounds.

Endophytic microbes, such as fungi, bacteria, and actinomycetes, can produce a variety of natural products, which are structurally unique and possess interesting biological and pharmacological activities. Owing to the specific ecological circumstances of mangroves, related endophytes have to cope with both terrestrial and marine environments, resulting in a great microbial diversity and metabolism specificity.

This Special Issue will focus on the recent research progresses in these interrelated disciplines. As a Guest Editor for this Special Issue of Marine Drugs, I invite you to submit your research findings on the mangroves and mangrove-associated microbes including those from the mangrove sediment ranging from the isolation and structure elucidation of new marine natural products to the mechanism studies of the novel bioactive compounds in this area.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mangroves
  • mangrove-associated microorganisms
  • endophytic microbes
  • mangrove-derived microbial metabolic diversity
  • marine microorganisms
  • marine pharmaceuticals
  • novel therapeutic agents
  • bioactive compounds
  • marine natural products

Published Papers (3 papers)

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Research

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Open AccessArticle New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
Mar. Drugs 2018, 16(4), 108; https://doi.org/10.3390/md16040108
Received: 9 February 2018 / Revised: 16 March 2018 / Accepted: 19 March 2018 / Published: 28 March 2018
PDF Full-text (1762 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (14), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The
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Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (14), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells. Full article
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
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Open AccessArticle Twenty-Nine New Limonoids with Skeletal Diversity from the Mangrove Plant, Xylocarpus moluccensis
Mar. Drugs 2018, 16(1), 38; https://doi.org/10.3390/md16010038
Received: 11 December 2017 / Revised: 10 January 2018 / Accepted: 17 January 2018 / Published: 19 January 2018
Cited by 1 | PDF Full-text (5823 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N,
[...] Read more.
Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove plant, Xylocarpus moluccensis. Compounds 113 are mexicanolides with one double bond or two conjugated double bonds, while 14 belongs to a small group of mexicanolides with an oxygen bridge between C1 and C8. Compounds 1519 are khayanolides containing a Δ8,14 double bond, whereas 20 and 21 are rare khayanolides containing a Δ14,15 double bond and Δ8,9, Δ14,15 conjugated double bonds, respectively. Compounds 22 and 23 are unusual limonoids possessing a (Z)-bicyclo[5.2.1]dec-3-en-8-one motif, while 24 and 25 are 30-ketophragmalins with Δ8,9, Δ14,15 conjugated double bonds. Compounds 26 and 27 are phragmalin 8,9,30-ortho esters, whereas 28 and 29 are azadirone and andirobin derivatives, respectively. The structures of these compounds, including absolute configurations of 1519, 2123, and 26, were established by HRESIMS, extensive 1D and 2D NMR investigations, and the comparison of experimental electronic circular dichroism (ECD) spectra. The absolute configuration of 1 was unequivocally established by single-crystal X-ray diffraction analysis, obtained with Cu Kα radiation. The diverse cyclization patterns of 129 reveal the strong flexibility of skeletal plasticity in the limonoid biosynthesis of X. moluccensis. Compound 23 exhibited weak antitumor activity against human triple-negative breast MD-MBA-231 cancer cells with an IC50 value of 37.7 μM. Anti-HIV activities of 1, 3, 8, 10, 11, 14, 20, 2325, and 27 were tested in vitro. However, no compounds showed potent inhibitory activity. Full article
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
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Review

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Open AccessReview Lead Compounds from Mangrove-Associated Microorganisms
Mar. Drugs 2018, 16(9), 319; https://doi.org/10.3390/md16090319
Received: 7 August 2018 / Revised: 22 August 2018 / Accepted: 29 August 2018 / Published: 7 September 2018
PDF Full-text (10466 KB) | HTML Full-text | XML Full-text
Abstract
The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical scaffolds, including those with potential medicinal application. In the past two decades, mangrove-derived microorganisms, along with mangrove plants, proved to be
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The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical scaffolds, including those with potential medicinal application. In the past two decades, mangrove-derived microorganisms, along with mangrove plants, proved to be rich sources of bioactive secondary metabolites as exemplified by the constant rise in the number of publications, which suggests the great potential of this important ecological niche. The present review summarizes selected examples of bioactive compounds either from mangrove endophytes or from soil-derived mangrove fungi and bacteria, covering the literature from 2014 to March 2018. Accordingly, 163 natural products are described in this review, possessing a wide range of potent bioactivities, such as cytotoxic, antibacterial, antifungal, α-glucosidase inhibitory, protein tyrosine phosphatase B inhibitory, and antiviral activities, among others. Full article
(This article belongs to the Special Issue Bioactive Compounds from Mangroves and Their-Associated Microbes)
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