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Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications

Department of Earth, Environment and Life Sciences, University of Genova, Corso Europa 26, 16132 Genova, Italy
Biophysics Institute, National Research Council (CNR), via De Marini 6, 16149 Genova, Italy
Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV 5, 16132 Genova, Italy
Department of Sciences and Technological Innovation, University of Eastern Piedmont, Viale T. Michel 11, 15121 Alessandria, Italy
Department of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
Department of Pharmacy, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy
Author to whom correspondence should be addressed.
Mar. Drugs 2018, 16(1), 21;
Received: 6 November 2017 / Revised: 14 December 2017 / Accepted: 8 January 2018 / Published: 10 January 2018
PDF [1930 KB, uploaded 10 January 2018]


Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves of Posidonia oceanica (L.) Delile, family Potamogetonaceae, herein named Posidonia ethanolic extract (PEE). PEE showed high radical scavenging activity, high phenolic content, and resulted rich in chicoric acid, as determined through HPLC-MS analysis. The use of MTT assay on fibroblasts showed a PEE cytotoxicity threshold (IC05) of 50 µg/mL at 48 h, while a sub-toxic dose of 20 µg/mL induced a significant increase of fibroblast growth rate after 10 days. In addition, an ELISA assay revealed that PEE doses of 5 and 10 µg/mL induced collagen production in fibroblasts. PEE induced dose-dependent mushroom tyrosinase inhibition, up to about 45% inhibition at 1000 µg/mL, while 50% reduction of melanin was observed in melanoma cells exposed to 50 µg/mL PEE. Finally, PEE lipolytic activity was assessed by measuring glycerol release from adipocytes following triglyceride degradation. In conclusion, we have collected new data about the biological activities of the phytocomplex of P. oceanica seagrass on skin cells. Our findings indicate that PEE could be profitably used in the development of products for skin aging, undesired hyperpigmentation, and cellulite. View Full-Text
Keywords: adipocytes; chicoric acid; collagen type I; fibroblasts; lipolysis; melanin; tyrosinase adipocytes; chicoric acid; collagen type I; fibroblasts; lipolysis; melanin; tyrosinase

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Cornara, L.; Pastorino, G.; Borghesi, B.; Salis, A.; Clericuzio, M.; Marchetti, C.; Damonte, G.; Burlando, B. Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications. Mar. Drugs 2018, 16, 21.

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