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Open AccessArticle

Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2018, 16(1), 25;
Received: 2 November 2017 / Revised: 2 December 2017 / Accepted: 8 January 2018 / Published: 12 January 2018
(This article belongs to the Collection Marine Drugs in the Management of Metabolic Diseases)
PDF [2207 KB, uploaded 12 January 2018]


Seven new polyketides, named tanzawaic acids R–X (16, 11), along with seven known analogues (710 and 1214), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses and chemical derivatization. Five compounds (2, 3, 6, 10 and 12) significantly decreased the oleic acid (OA)-elicited lipid accumulation in HepG2 liver cells at the concentration of 10 μM, among which, four compounds (3, 6, 10 and 12) significantly decreased intracellular total cholesterol (TC) levels and three Compounds (3, 6, and 10) significantly decreased intracellular triglyceride (TG) levels. Moreover, the TG-lowering capacities of compounds 6 and 10 were comparable with those of simvastatin, with the TG levels being nearly equal to blank control. This is the first report on the lipid-lowering activity of tanzawaic acid derivatives. View Full-Text
Keywords: Penicillium steckii; tanzawaic acid derivatives; lipid-lowering activity Penicillium steckii; tanzawaic acid derivatives; lipid-lowering activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yu, G.; Wang, S.; Wang, L.; Che, Q.; Zhu, T.; Zhang, G.; Gu, Q.; Guo, P.; Li, D. Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279. Mar. Drugs 2018, 16, 25.

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