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Marine Drugs, Volume 16, Issue 1

January 2018 - 38 articles

Cover Story: Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and subtropical oceans. Aaptamine, demethyloxyaaptamine, and isoaaptamine were isolated from Aaptos sp. methanolic extract. In this study, we sought to elucidate the cytotoxic activity of aaptamine alkaloids in vitro along with their mechanism of action. The effect of IAp treatment on ROS generation and ER stress-related proteins in breast T-47D cancer cells was evaluated showing an enhancement in ROS generation as well as IRE 1α and Bip expression. Based on the results that ROS and ER stress are involved in IAp effect on T-47D cells, we hypothesized that the induction of apoptosis and autophagy might be attributed to mitochondrial dysfunction-dependent apoptosis and Nrf2/p62 dependent autophagy.
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Articles (38)

  • Article
  • Open Access
49 Citations
6,780 Views
18 Pages
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Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress

  • Chih-Fung Wu,
  • Man-Gang Lee,
  • Mohamed El-Shazly,
  • Kuei-Hung Lai,
  • Seng-Chung Ke,
  • Chiang-Wen Su,
  • Shou-Ping Shih,
  • Ping-Jyun Sung,
  • Ming-Chang Hong and
  • Zhi-Hong Wen
  • + 1 author
Mar. Drugs2018, 16(1), 18;https://doi.org/10.3390/md16010018

9 January 2018

Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and...

Full Article
  • Article
  • Open Access
33 Citations
6,905 Views
16 Pages
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Effect of Low Molecular Weight Oligopeptides Isolated from Sea Cucumber on Diabetic Wound Healing in db/db Mice

  • Di Li,
  • Lin Li,
  • Teng Xu,
  • Tianxing Wang,
  • Jinwei Ren,
  • Xinran Liu and
  • Yong Li
Mar. Drugs2018, 16(1), 16;https://doi.org/10.3390/md16010016

8 January 2018

Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the woun...

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  • Communication
  • Open Access
19 Citations
6,803 Views
10 Pages
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Difference in Uptake of Tetrodotoxin and Saxitoxins into Liver Tissue Slices among Pufferfish, Boxfish and Porcupinefish

  • Yuji Nagashima,
  • Akira Ohta,
  • Xianzhe Yin,
  • Shoichiro Ishizaki,
  • Takuya Matsumoto,
  • Hiroyuki Doi and
  • Toshiaki Ishibashi
Mar. Drugs2018, 16(1), 17;https://doi.org/10.3390/md16010017

8 January 2018

Although pufferfish of the family Tetraodontidae contain high levels of tetrodotoxin (TTX) mainly in the liver, some species of pufferfish, boxfish of the family Ostraciidae, and porcupinefish of the family Diodontidae do not. To clarify the mechanis...

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  • Article
  • Open Access
21 Citations
7,128 Views
12 Pages
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Aquaculture Soft Coral Lobophytum crassum as a Producer of Anti-Proliferative Cembranoids

  • Bo-Rong Peng,
  • Mei-Chin Lu,
  • Mohamed El-Shazly,
  • Shwu-Li Wu,
  • Kuei-Hung Lai and
  • Jui-Hsin Su
Mar. Drugs2018, 16(1), 15;https://doi.org/10.3390/md16010015

7 January 2018

Our continuous search for marine bioactive secondary metabolites led to the screening of crude extracts from a variety of aquaculture soft corals. The ethyl acetate (EtOAc) extract of Lobophytum crassum showed a distinctive chemical profile that was...

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  • Feature Paper
  • Review
  • Open Access
64 Citations
8,111 Views
15 Pages
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Secondary Metabolites of Mangrove-Associated Strains of Talaromyces

  • Rosario Nicoletti,
  • Maria Michela Salvatore and
  • Anna Andolfi
Mar. Drugs2018, 16(1), 12;https://doi.org/10.3390/md16010012

6 January 2018

Boosted by the general aim of exploiting the biotechnological potential of the microbial component of biodiversity, research on the secondary metabolite production of endophytic fungi has remarkably increased in the past few decades. Novel compounds...

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  • Article
  • Open Access
9 Citations
5,730 Views
16 Pages
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Functional Expression and Characterization of the Recombinant N-Acetyl-Glucosamine/N-Acetyl-Galactosamine-Specific Marine Algal Lectin BPL3

  • Hyun-Ju Hwang,
  • Jin-Woo Han,
  • Gwang Hoon Kim and
  • Jong Won Han
Mar. Drugs2018, 16(1), 13;https://doi.org/10.3390/md16010013

5 January 2018

Lectins, characterized by their carbohydrate-binding ability, have extensive practical applications. However, their industrial use is limited due to impurity. Thus, quality-controlled production of recombinant lectin is necessary. In this study, the...

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  • Article
  • Open Access
28 Citations
6,115 Views
9 Pages
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Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.

  • Hee Jae Shin,
  • Byeoung-Kyu Choi,
  • Phan Thi Hoai Trinh,
  • Hwa-Sun Lee,
  • Jong Soon Kang,
  • Tran Thi Thanh Van,
  • Hyi-Seung Lee,
  • Jong Seok Lee,
  • Yeon-Ju Lee and
  • Jihoon Lee
Mar. Drugs2018, 16(1), 14;https://doi.org/10.3390/md16010014

5 January 2018

A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the...

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  • Article
  • Open Access
64 Citations
6,491 Views
9 Pages
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The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation

  • Thanh Sang Vo,
  • Se-Kwon Kim,
  • BoMi Ryu,
  • Dai Hung Ngo,
  • Na-Young Yoon,
  • Long Giang Bach,
  • Nguyen Thi Nhat Hang and
  • Dai Nghiep Ngo
Mar. Drugs2018, 16(1), 1;https://doi.org/10.3390/md16010001

4 January 2018

UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for...

Full Article
  • Article
  • Open Access
7 Citations
4,930 Views
8 Pages
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Formation of Silver Nanoparticles Using Fluorescence Properties of Chitosan Oligomers

  • Ja Young Cheon,
  • Hun Min Lee and
  • Won Ho Park
Mar. Drugs2018, 16(1), 11;https://doi.org/10.3390/md16010011

3 January 2018

In this study, silver chloride nanoparticles (AgCl NPs) were prepared using chitosan oligomer (CHI) and chitosan oligomer derivatives (CHI-FITC). The CHI and CHI-FITC were used as markers to confirm the formation of AgCl NPs using their fluorescence...

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Mar. Drugs - ISSN 1660-3397
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