Pharmaceuticals, Volume 18, Issue 4
2025 April - 162 articles
Cover Story: Lithium is an alkali metal found in mineral form in nature, from which it can be extracted and processed into various lithium salts. Research on lithium’s use as a neuroprotector in Alzheimer’s disease (AD) and other neurodegenerative diseases is grounded in its well-established role as a mood stabilizer. Preclinical studies have shown that lithium, a potent inhibitor of the enzyme glycogen synthase kinase-3β (GSK-3β), can reduce amyloid and tau pathology, attenuate neuronal cell death, and improve cognitive function in animal models of AD. Translational research indicates that lithium may protect against AD by reducing apoptosis, inflammation, and oxidative stress and stimulating neurotrophic factors. This review outlines the timeline from lithium’s discovery to the current understanding of its properties and provides an overview of its main mechanisms of neuroprotective action. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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