Natural Products-Assisted Organic Synthesis in Medicinal Chemistry
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 June 2025 | Viewed by 1872
Special Issue Editors
Interests: palladium complexes; curcuminoids; cytotoxicity; structural characterization of organic compounds; synthesis of organic compounds; synthesis of bio-inorganic compounds; coordination chemistry
Interests: oncology; biomarkers; bioinorganic chemistry; immunology; chemotherapy; biochemistry; translational medicine; cell biology; radiobiology; nanostructures
Special Issue Information
Dear Colleagues,
Natural products have been used as remedies as a form alternative medicine since ancient times. Many of the isolated organic compounds from plants have been proven to be biologically active and used as antifungal, antimicrobial, anti-inflammatory, antitussive, analgetic, antipyretic, and antioxidant agents, essentially contributing to medicine and pharmacotherapy. Generally, plant extracts also have disadvantages, whereby either the extracted amount of an active compound does not fulfill the requested quantity due to low natural abundance or the isolation of the active component as a pure biological active substance can be a strenuous process, which causes adverse side effects of the naturally extracted drug. The total synthesis of natural organic compounds and their derivatives supports the preparative aspects of a range of molecules of plant origins. In this regard, the limitations of the extracts are reduced, and the possibility of deriving natural products by generating synthetic analogs with improved biological activity can be afforded. Currently, various synthetic organic compounds are used in the prevention and treatment of cancer; rheumatic, cardiovascular, and neurodegenerative illnesses; and so forth. The diversity and availability of synthetic methods of organic compounds similar to natural products afford benefits, especially in the medical area.
Dr. Natalia Miklášová
Dr. Eva Fischer-Fodor
Guest Editors
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Keywords
- total organic synthesis
- preparative methods of natural products
- natural carboxylic acids
- derivatives of organic carboxylic acids
- amino acids
- carbonyl derivatives
- phenolic compounds
- heterocyclic compounds
- antioxidant activity
- antifungal activity
- antimicrobial activity
- anti-inflammatory activity
- cytotoxicity
- anti-cancer activity
- ROS activity
- DNA damages
- structure-activity studies
- DFT calculations for synthetic organic products
- molecular docking
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