New Platforms for Cancer Treatment—Emerging Advances

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 880

Special Issue Editors


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Department of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Interests: nonclinical animal models; in vitro activity; experimental chemotherapy; experimental drugs; nanoformulations; cardiotoxicity; neglected diseases and cancer treatment
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School of Pharmacy; Federal University of Ouro Preto, Ouro Preto 35400-000, Minas Gerais, Brazil
Interests: polymers; polymers synthesis; biodegradable and decorated polymeric nanocarriers; parasitic diseases and cancer treatment
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Pharmacy; Federal University of Ouro Preto, Ouro Preto, MG, Brazil
Interests: pre-clinical mice models; cytotoxicity; efficacy; experimental chemotherapy; cardiotoxicity
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School of Pharmacy, Federal University of Ouro Preto, Department of Pharmacy - Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Campus Universitário Morro do Cruzeiro, 35400-000 Ouro Preto, MG, Brazil
Interests: polymeric nanoparticles; biodistribution; oral lipid-based nanosystems; efficacy; biodistribution; pharmaceutical nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this Special Issue, “New Platforms for Cancer Treatment—Emerging Advances”, is to gather high-quality papers in the field and address pharmaceutical strategies focused on cancer treatment. The alarming rise of cancer cases has become a significant public health concern in recent decades. According to the WHO, ten million people died from cancer alone in 2020, regardless of age or social status. Cancer treatment encompasses various approaches, including surgery, radiotherapy, and conventional chemotherapy, often used in drug combinations. Adverse effects are commonly manifested acutely and chronically.

Nanotechnology has emerged as a more selective option for cancer treatment. It offers targeted therapy, biodistribution, and reduced toxicity. Another strategy for advancing cancer treatment is based on gene therapy, including DNA microRNAs, oncolytic virotherapy, and gene-directed enzyme pro-drug deliveries. Efforts to discover new active molecules or novel combinations continue as a strong branch of cancer treatment novelty. Photodynamic (PDT) and photothermal (PTT) cancer therapies are emerging as new options for the counterpart mutilation of organs and tissues. Monoclonal antibodies in cancer treatment represent a great breakthrough in personalized cancer treatment. These antibodies have been used to target nanostructures loaded with different drugs to tumoral areas in the human body with success.

We encourage researchers from the pharmaceutical and health science disciplines to contribute original and review manuscripts highlighting the latest developments in this field. We welcome manuscripts covering in vitro and in vivo screenings and pre-clinical studies with diverse applications to cancer treatment.

The scope of this Special Issue includes the following:

  • Novel drugs or active compounds for cancer treatment;
  • Nanostructures applied to cancer treatment;
  • Use of photodynamics and photothermal agents in nanotheranostics;
  • Targeting approaches to improve selectivity in cancer;
  • Biopharmaceutical studies of antitumoral drugs associated with nanodevices;
  • Reviews of current and up-to-date research in cancer treatment and new strategies.

Dr. Fernanda Karoline Vieira da Silva Torchelsen
Dr. Maria Alice de Oliveira
Dr. Renata Tupinambá Branquinho
Prof. Dr. Vanessa Carla Furtado Mosqueira
Guest Editors

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Keywords

  • cancer treatment
  • emerging advances
  • nanotechnology
  • nanotheranostics
  • novel drugs
  • nanostructures
  • pre-clinical studies

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Published Papers (1 paper)

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20 pages, 2359 KiB  
Article
Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma
by Mikoto Onodera, Shuji Kitahara, Yasuto Sato, Takakazu Kawamata, Yoshihiro Muragaki and Ken Masamune
Pharmaceuticals 2025, 18(4), 583; https://doi.org/10.3390/ph18040583 - 16 Apr 2025
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Abstract
Background: Although extensive resection improves the prognosis of gliomas, it risks impairing critical brain functions. Photodynamic therapy (PDT) utilizing talaporfin sodium (TS) targets tumor cells upon light activation. Despite its approval in Japan, TS application remains restricted, and factors influencing its efficacy are [...] Read more.
Background: Although extensive resection improves the prognosis of gliomas, it risks impairing critical brain functions. Photodynamic therapy (PDT) utilizing talaporfin sodium (TS) targets tumor cells upon light activation. Despite its approval in Japan, TS application remains restricted, and factors influencing its efficacy are unclear. We aimed to identify TS efficacy determinants to optimize treatment outcomes. Methods: Data from 171 patients with grade 4 glioma who underwent surgery and PDT at Tokyo Women’s Medical University Hospital between January 2017 and March 2024 were retrospectively analyzed. Clinical variables evaluated included age, sex, genotype, Karnofsky Performance Status (KPS), serum albumin (Alb) levels, MIB-1 expression levels, and medication history. TS concentrations in tumor tissues were quantitatively assessed in 82 patients (41 primary, 41 recurrent). Survival outcomes were analyzed. RNA-seq was performed on the three highest and three lowest TS concentration samples with significant TS concentration variations to investigate corresponding gene expression changes. Results: Multivariate analysis identified KPS (hazard ratio [95% confidence interval]: 0.96 [0.93–0.99], p = 0.01) and Alb (3.68 [1.05–13.76], p = 0.047) as independent prognostic factors. In recurrent cases, higher TS concentrations were significantly associated with improved survival (p = 0.0454). RNA-seq analysis indicated decreased expression of ACTB and PDPN genes in samples with lower TS concentrations, suggesting potential resistance mechanisms. Conclusions: TS concentration is a critical determinant of PDT efficacy, especially in recurrent glioma, highlighting its prognostic significance. Alb may affect treatment outcomes by mediating TS binding. RNA-seq findings imply that low TS concentrations may suppress immune and stress response-related genes, potentially diminishing PDT sensitivity. Full article
(This article belongs to the Special Issue New Platforms for Cancer Treatment—Emerging Advances)
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