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21 Results Found

  • Article
  • Open Access
66 Citations
8,544 Views
17 Pages

3D Printed Punctal Plugs for Controlled Ocular Drug Delivery

  • Xiaoyan Xu,
  • Sahar Awwad,
  • Luis Diaz-Gomez,
  • Carmen Alvarez-Lorenzo,
  • Steve Brocchini,
  • Simon Gaisford,
  • Alvaro Goyanes and
  • Abdul W. Basit

Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of to...

  • Article
  • Open Access
7 Citations
2,511 Views
8 Pages

21 April 2022

This study analyzed the microbiologic results of removing silicone punctal plugs due to uncomfortable symptoms in dry-eye patients. Patients who were diagnosed with dry eye and received silicone punctal plugs—SuperEagle Punctum Plug™ (Eag...

  • Article
  • Open Access
2 Citations
3,056 Views
8 Pages

Differential Bacterial Colonization and Biofilm Formation on Punctal Occluders

  • Michael Hadjiargyrou,
  • Eric D. Donnenfeld,
  • Lola M. Grillo and
  • Henry D. Perry

16 January 2019

Dry eye is a common condition that is treated primarily by topical lubricants, immunomodulation, and a variety of punctal and canalicular plugs (occluders). Biofilm formation has been reported as an ongoing problem with the clinical use of occluders....

  • Article
  • Open Access
2 Citations
3,134 Views
13 Pages

Effect of Punctal Occlusion on Blinks in Eyes with Severe Aqueous Deficient Dry Eye

  • Hiroaki Kato,
  • Norihiko Yokoi,
  • Akihide Watanabe,
  • Aoi Komuro,
  • Yukiko Sonomura,
  • Chie Sotozono and
  • Shigeru Kinoshita

Punctal occlusion (PO) is considered to improve both tear-film instability and increased friction during blinking and may consequently affect blinks. The purpose of this study was to investigate the effect of PO on blinks. This study involved 16 eyes...

  • Article
  • Open Access
9 Citations
3,477 Views
9 Pages

Comparison of Treatment Modalities for Dry Eye in Primary Sjögren’s Syndrome

  • Hyunmin Ahn,
  • Yong Woo Ji,
  • Ikhyun Jun,
  • Tae-im Kim,
  • Hyung Keun Lee and
  • Kyoung Yul Seo

17 January 2022

Purpose: To evaluate the effectiveness of different treatment modalities for dry eye in primary Sjögren’s syndrome with their potential overlapping influences. Methods: This study included 199 patients with newly diagnosed primary Sjö...

  • Article
  • Open Access
1,727 Views
9 Pages

The Use of Venous Catheter and Irrigation with Povidone-Iodine 0.6% in Patients with Punctal and Proximal Canalicular Stenosis: Preliminary Report

  • Claudia Azzaro,
  • Alessandro Meduri,
  • Giovanni William Oliverio,
  • Laura De Luca,
  • Francesco Gazia,
  • Francesco Franchina and
  • Pasquale Aragona

26 February 2024

Background: This study aimed to evaluate the safety and efficacy of povidone-iodine 0.6% (PVI) irrigation for preventing recurrence of stenosis after punctoplasty in patients with punctal and proximal canalicular stenosis treated using a venous cathe...

  • Review
  • Open Access
59 Citations
10,712 Views
15 Pages

Ocular Drug Delivery for Glaucoma Management

  • Nathan Gooch,
  • Sarah A. Molokhia,
  • Russell Condie,
  • Randon Michael Burr,
  • Bonnie Archer,
  • Balamurali K. Ambati and
  • Barbara Wirostko

Current glaucoma management modalities are hindered by low patient compliance and adherence. This can be due to highly complex treatment strategies or poor patient understanding. Treatments focus on the management or reduction of intraocular pressure...

  • Article
  • Open Access
2 Citations
3,152 Views
10 Pages

Botulinum Neurotoxin Type a Injection Combined with Absorbable Punctal Plug Insertion: An Effective Therapy for Blepharospasm Patients with Dry Eye

  • Malachie Ndikumukiza,
  • Yu-Ting Xiao,
  • You-Fan Ye,
  • Jia-Song Wang,
  • Xi Peng,
  • Hua-Tao Xie and
  • Ming-Chang Zhang

22 January 2023

Blepharospasm patients often have dry eye manifestations. Botulinum neurotoxin type A (BoNT-A) injection has been the main management for blepharospasm and absorbable punctal plug (APP) insertion is shown to be effective in the treatment of dry eye....

  • Review
  • Open Access
5 Citations
7,279 Views
17 Pages

Drug Delivery Systems for Glaucoma: A Narrative Review

  • Antonio M. Fea,
  • Veronica Vallino,
  • Michela Cossu,
  • Valentina Marica,
  • Cristina Novarese,
  • Michele Reibaldi and
  • Francesco Petrillo

2 September 2024

Glaucoma is one of the world’s leading causes of blindness, and its management is challenging. The main objective is to lower intraocular pressure through medical, para-surgical, and surgical therapy. Medical therapy often represents the first...

  • Article
  • Open Access
1 Citations
1,538 Views
12 Pages

Eye Pain Caused by Epithelial Damage in the Central Cornea in Aqueous-Deficient Dry Eye

  • Yamato Yoshikawa,
  • Norihiko Yokoi,
  • Natsuki Kusada,
  • Hiroaki Kato,
  • Rieko Sakai,
  • Aoi Komuro,
  • Yukiko Sonomura and
  • Chie Sotozono

In this study, the severity of eye pain (EP) and associated objective findings were evaluated in aqueous-deficient dry eye (ADDE) patients using PainVision®, a quantitative pain-measuring device. This study involved 53 eyes of 53 ADDE patients (6 mal...

  • Review
  • Open Access
3,260 Views
21 Pages

Oculoplastic Interventions in the Management of Ocular Surface Diseases: A Comprehensive Review

  • Seyed Mohsen Rafizadeh,
  • Hassan Asadigandomani,
  • Samin Khannejad,
  • Arman Hasanzade,
  • Kamran Rezaei,
  • Avery Wei Zhou and
  • Mohammad Soleimani

16 July 2025

This study aimed to comprehensively review surgical interventions for ocular surface diseases (OSDs), including dry eye syndrome (DES), exposure keratopathy, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and ocular graft versus ho...

  • Review
  • Open Access
12 Citations
11,668 Views
27 Pages

Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review

  • Basanta Bhujel,
  • Se-Heon Oh,
  • Chang-Min Kim,
  • Ye-Ji Yoon,
  • Ho-Seok Chung,
  • Eun-Ah Ye,
  • Hun Lee and
  • Jae-Yong Kim

Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered by various factors. This condition can lead to tear deficiencies, resulti...

  • Case Report
  • Open Access
18 Citations
4,951 Views
17 Pages

The first product in the world for ex vivo cultivated oral mucosal epithelial cell transplantation (COMET) to treat limbal stem cell deficiency (LSCD), named Ocural®, was launched in June 2021 in Japan. COMET was performed on two patients, includ...

  • Article
  • Open Access
2,635 Views
6 Pages

Evaluation of Bicanalicular Nasolacrimal Duct Intubation as an Adjunct in Surgical Ectropion Correction

  • Anthia Papazoglou,
  • Triantafyllia Chrysochoou,
  • David Goldblum,
  • Markus Tschopp and
  • Tim J. Enz

4 August 2022

Background and Objectives: We aimed to analyze and compare the outcomes of conventional ectropion surgery procedures with and without concurrent bicanalicular nasolacrimal duct intubation to identify if the combination of procedures could serve as a...

  • Review
  • Open Access
1 Citations
3,085 Views
24 Pages

Three-Dimensional Printing for Accessible and Personalized Ophthalmic Care: A Review

  • Mina Mina,
  • Ajay Kumar Goel,
  • Fady Mina,
  • Doris Goubran and
  • Nand Goel

Over 2.2 billion people across the globe face significant barriers to accessing essential ophthalmic care, with elderly, rural, and refugee populations being disproportionately affected, deepening existing disparities in eye care. Three-dimensional p...

  • Article
  • Open Access
696 Views
7 Pages

27 June 2025

Background and Objectives: This study reports an association between nasolacrimal duct obstruction (NLDO) and perinasal uptake on radioactive iodine (RAI) whole-body scan. Materials and Methods: This is a retrospective study of 37 patients from May t...

  • Systematic Review
  • Open Access
3,605 Views
20 Pages

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Ophthalmic Management and Treatment

  • Korolos Sawires,
  • Brendan K. Tao,
  • Harrish Nithianandan,
  • Larena Menant-Tay,
  • Michael O’Connor,
  • Peng Yan and
  • Parnian Arjmand

11 September 2025

Background: Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare, life-threatening mucocutaneous disorders often associated with severe ophthalmic complications. Ocular involvement occurs in 50–68% of cases and can...

  • Case Report
  • Open Access
2,335 Views
9 Pages

Neuronal Intranuclear Inclusion Disease with a Corneal Disorder: A Case Report

  • Mohamed Talaat Mohamed,
  • Daisuke Inoue,
  • Shunsuke Yoshimura,
  • Masafumi Uematsu,
  • Yasser Helmy Mohamed,
  • Mao Kusano,
  • Diya Tang,
  • Akio Oishi,
  • Takashi Kitaoka and
  • Gou Takeo
  • + 1 author

22 October 2024

Background: Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disorder characterized by the formation of intranuclear inclusions in cells. Adult-type NIID usually develops in elderly patients with various clinical mani...

  • Case Report
  • Open Access
7 Citations
3,458 Views
7 Pages

Refractory Dry Eye Syndrome after Transconjunctival Excision of the Palpebral Lobe of the Lacrimal Gland

  • Yong-Jae Lee,
  • Han-Sol Choi,
  • Seong-Jun Park,
  • Hae-Jung Sun and
  • Sun-Young Jang

11 June 2021

The aim of the present study was to report two cases of refractory dry eye syndrome (DES) after transconjunctival excision of the palpebral lobe of the lacrimal gland. A 25-year-old female patient with a chief complaint of a palpable mass in both upp...

  • Review
  • Open Access
3 Citations
6,390 Views
24 Pages

Background/Objectives: Dry eye disease (DED) is a multifactorial condition with complex pathophysiology involving tear film instability, ocular surface inflammation, and nerve dysfunction. This review summarizes current evidence on the different avai...

  • Review
  • Open Access
791 Views
19 Pages

Eyelid Malpositions and Ocular Surface Disease: Clinical Correlations and Management Strategies

  • Francesco M. Quaranta Leoni,
  • Nazareno Marabottini,
  • Adriana Iuliano,
  • Diego Strianese and
  • Gustavo Savino

1 December 2025

Eyelid retraction, cicatricial entropion, and deformities associated with facial nerve palsy are among the eyelid malpositions most detrimental to the ocular surface, as they cause exposure, tear film instability, inflammation, and potentially signif...