Ocular Drug Delivery for Glaucoma Management
Abstract
:1. Glaucoma: The Silent Thief of Sight
2. Ocular Drug Delivery
3. Delivery Devices in Preclinical Development
3.1. External Pumps
3.2. Contact Lenses
3.3. Sub-conjunctival Injections
4. Delivery Devices in Clinical Development
Company | Drug | Delivery Method | Clinical Development | status |
---|---|---|---|---|
pSivida Corp. | Latanoprost | Subconjunctival/Perilimbal | Phase I/II | recruiting |
Alcon | Anecortave | Subconjunctival/Subtenons | Phase II/III | discontinued |
Allergan | Brimonidine | Intravitreal | Phase II | ongoing |
QLT | Latanoprost | Punctal plug | Phase II | completed |
Aerie | Latanoprost | Subconjunctival suture fixation | Projected to start Phase I/II in 2012 | ongoing |
4.1. Punctal Plugs
4.2. Conjunctival Inserts
4.3. Subconjunctival Inserts
4.4. Intravitreal Inserts
4.5. Drug Depots: Anecortave Acetate
5. Conclusions
5.1. Market Considerations for the Ideal Delivery Product
5.2. The Future of Glaucoma Drug Delivery
Conflict of Interest
References
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Gooch, N.; Molokhia, S.A.; Condie, R.; Burr, R.M.; Archer, B.; Ambati, B.K.; Wirostko, B. Ocular Drug Delivery for Glaucoma Management. Pharmaceutics 2012, 4, 197-211. https://doi.org/10.3390/pharmaceutics4010197
Gooch N, Molokhia SA, Condie R, Burr RM, Archer B, Ambati BK, Wirostko B. Ocular Drug Delivery for Glaucoma Management. Pharmaceutics. 2012; 4(1):197-211. https://doi.org/10.3390/pharmaceutics4010197
Chicago/Turabian StyleGooch, Nathan, Sarah A. Molokhia, Russell Condie, Randon Michael Burr, Bonnie Archer, Balamurali K. Ambati, and Barbara Wirostko. 2012. "Ocular Drug Delivery for Glaucoma Management" Pharmaceutics 4, no. 1: 197-211. https://doi.org/10.3390/pharmaceutics4010197
APA StyleGooch, N., Molokhia, S. A., Condie, R., Burr, R. M., Archer, B., Ambati, B. K., & Wirostko, B. (2012). Ocular Drug Delivery for Glaucoma Management. Pharmaceutics, 4(1), 197-211. https://doi.org/10.3390/pharmaceutics4010197