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30 Results Found

  • Article
  • Open Access
4 Citations
2,872 Views
12 Pages

Safety and Tolerability of Whole Soybean Products: A Dose-Escalating Clinical Trial in Older Adults with Obesity

  • Candida J. Rebello,
  • Stephen Boué,
  • Ronald J. Levy,
  • Renée Puyau,
  • Robbie A. Beyl,
  • Frank L. Greenway,
  • Mark L. Heiman,
  • Jeffrey N. Keller,
  • Charles F. Reynolds and
  • John P. Kirwan

16 April 2023

Soybean products have nutrients, dietary fiber, and phytoalexins beneficial for cardiovascular and overall health. Despite their high consumption in Asian populations, their safety in Western diets is debated. We conducted a dose-escalating clinical...

  • Article
  • Open Access
1 Citations
1,014 Views
21 Pages

25 June 2025

Object-related accidents among older adults often result from inadequately designed furniture and fixtures that do not accommodate age-related changes. However, technologies for quantitatively capturing how furniture and fixtures assist the body in d...

  • Article
  • Open Access
4 Citations
2,827 Views
12 Pages

Feasibility of Child-Resistant and Senior-Friendly Press-Through Packages: Potential of Different Materials

  • Kiyomi Sadamoto,
  • Hiroyuki Ura,
  • Mikio Murata,
  • Masaho Hayashi and
  • Kiyoshi Kubota

Press-through packaging (PTP) is the most common type of drug packaging in Japan, and a production procedure for PTP has been established at an acceptable cost. However, unknown problems and new needs with regard to safety among users of various age-...

  • Article
  • Open Access
5 Citations
4,057 Views
20 Pages

23 August 2024

As numerous nations transition into digital and aging societies, the digital divide has emerged as a significant impediment to older adults’ autonomous engagement in the digital society. Enhancing the well-being of elderly individuals through r...

  • Article
  • Open Access
626 Views
15 Pages

A Study on the Acceptance of Smart Cane Technology Among Chinese Older Adults

  • Yibing Chen,
  • Yi An,
  • Zihao Chen,
  • Dingbang Luh and
  • Tiansheng Xia

16 November 2025

Background: Although smart products improve older adults’ quality of life, their acceptance and usage of smart assistive devices remain relatively low, and the influencing factors remain unclear. Methods: This study takes canes, which are commo...

  • Article
  • Open Access
46 Citations
7,462 Views
15 Pages

Characteristics of Older Adults Who Were Early Adopters of Medical Cannabis in the Florida Medical Marijuana Use Registry

  • Joshua D. Brown,
  • Brianna Costales,
  • Sascha van Boemmel-Wegmann,
  • Amie J. Goodin,
  • Richard Segal and
  • Almut G. Winterstein

18 April 2020

Use of medical marijuana is increasing in the United States and older adults are the fastest growing user group. There is little information about the characteristics and outcomes related to medical marijuana use. This study is a descriptive analysis...

  • Article
  • Open Access
1,898 Views
15 Pages

Transforming Agri-Waste into Health Innovation: A Circular Framework for Sustainable Food Design

  • Smita Mortero,
  • Jirarat Anuntagool,
  • Achara Chandrachai and
  • Sanong Ekgasit

23 July 2025

This study addresses the problem of agricultural waste utilization and nutrition for older adults by developing a food product based on a circular design approach. Pineapple core was used to produce a clean-label dietary powder without chemical or en...

  • Article
  • Open Access
2 Citations
2,296 Views
17 Pages

Factors Influencing Elderly Consumers’ Preferences for Edible Gels: Insights from Slovakia

  • Melina Korčok,
  • Miroslav Veverka,
  • Kristina Nakonechna,
  • Simona Škrípová and
  • Vladimir Vietoris

24 September 2024

As dietary needs shift with the growing and aging population, there is a demand for food products that meet nutritional, safety, and tribological requirements while being cost-effective. Seniors must be given significant consideration in new product...

  • Article
  • Open Access
2 Citations
2,388 Views
17 Pages

MUS3E: A Mobility Ubiquitous Sensor Edge Environment for the Elderly

  • Tomihiro Utsumi,
  • Masatoshi Arikawa and
  • Masashi Hashimoto

With the ageing of society, the number of households with older individuals or couples living alone is increasing. An “ageing-in-place” approach allows older adults to continue to live at home and receive help only when needed. However, t...

  • Protocol
  • Open Access
3,639 Views
16 Pages

Effect of a Health Education Intervention to Reduce Fear of Falling and Falls in Older People: A Cluster Randomized Clinical Trial Protocol

  • Nuria Alcolea-Ruiz,
  • Candelas López-López,
  • Teresa Pérez-Pérez,
  • Sonia Alcolea,
  • FEARFALL_CARE Clinical Care Group and
  • Francisco Javier Pérez-Rivas

11 December 2024

Background/Objectives: Fear of falling (FOF) and falls are prevalent issues among older adults, leading to activity restriction, decreased quality of life, and increased dependency. This study aims to assess the effectiveness of a nurse-led health ed...

  • Article
  • Open Access
4 Citations
3,769 Views
23 Pages

31 October 2023

ThickenUp® Gel Express (TUGE) is a new, xanthan- and acacia-gum-based, liquid, thickening product. In independently living older adults with oropharyngeal dysphagia (OD), we assessed: (1) the rheological properties of TUGE; (2) its therapeutic ef...

  • Article
  • Open Access
2,024 Views
13 Pages

Trends and Risk Factors for the Hospitalization of Older Adults Presenting to Emergency Departments After a Bed-Related Fall: A National Database Analysis

  • Andy Tom,
  • Sergio M. Navarro,
  • Grant M. Spears,
  • Adam Schluttenhofer,
  • Michelle Junker,
  • John Zietlow,
  • Roderick Davis,
  • Allyson K. Palmer,
  • Nathan K. LeBrasseur and
  • Fernanda Bellolio
  • + 1 author

15 July 2025

Background/objectives: Falls are a leading cause of traumatic injury and hospitalization for adults over the age of 65. While common, bed-related falls are relatively understudied when compared to ambulatory falls. The aim of this study is to charact...

  • Review
  • Open Access
8,929 Views
20 Pages

Review of Supplements That Patients Commonly Report Using for Dementia

  • Alexander Frolov,
  • Audrey Wadood and
  • Brendan J. Kelley

11 December 2024

Dietary supplements are readily available over the counter in the United States and are used by the majority of older adults to address a variety of concerns and conditions. Many older adults report using dietary supplements for cognitive health&mdas...

  • Perspective
  • Open Access
1,035 Views
22 Pages

The Case for Advanced Recycling as a Path to Sustainable Food Packaging for Specialized Nutrition Products

  • Melvin A. Pascall,
  • Jameel Ahmed,
  • Mary Beth Arensberg,
  • Erica Ledbetter and
  • Lauren Cheetham

22 October 2025

Food packaging helps in labeling, transport, preservation, and the safety of food. Safety is especially critical in processing foods for vulnerable populations like infants/children, individuals with medical conditions, and older adults. These groups...

  • Review
  • Open Access
14 Citations
8,125 Views
18 Pages

Development, Current Status, and Remaining Challenges for Respiratory Syncytial Virus Vaccines

  • Cleo Anastassopoulou,
  • Snežana Medić,
  • Stefanos Ferous,
  • Fotini Boufidou and
  • Athanasios Tsakris

21 January 2025

Respiratory syncytial virus (RSV) causes significant morbidity and mortality, especially in young children and the elderly. RSV vaccine development puzzled vaccinologists for years. Safety concerns of initial formulations, the lack of an absolute cor...

  • Article
  • Open Access
1,230 Views
17 Pages

Safety, Tolerability, and Immunogenicity of aH5N1 Vaccine in Adults with and Without Underlying Immunosuppressive Conditions

  • Peter Malfertheiner,
  • Eve Versage,
  • Esther Van Twuijver,
  • Giuliano Rizzardini and
  • Matthew Hohenboken

1 April 2025

Background: Pandemic influenza may cause substantial morbidity and mortality, especially in older adults and those with immunosuppressive conditions. Methods: In this phase 3, stratified, randomized, controlled, observer-blind, multicenter trial, we...

  • Article
  • Open Access
3 Citations
5,415 Views
13 Pages

23 March 2022

A cell-based process may be better suited for vaccine production during a highly pathogenic avian influenza (HPAI) pandemic. This was a phase 3, randomized, controlled, observer-blind, multicenter study evaluated safety, immunogenicity, and lot-to-lo...

  • Review
  • Open Access
3,936 Views
32 Pages

European Consumer and Regulatory Trends in Medicinal Plant Food Supplements and Their Functional Properties: The Road from Farm to Fork

  • Mihaela Mihai,
  • Călina Ciont,
  • Oana-Lelia Pop,
  • Diana E. Dumitras,
  • Valentin C. Mihai,
  • Ionela Daniela Morariu and
  • Cristina Bianca Pocol

30 October 2025

The rising use of medicinal plant food supplements in Europe reflects a growing consumer shift toward natural health solutions and sustainability-driven lifestyles. The study aims to synthesize current literature and regulatory frameworks to better u...

  • Article
  • Open Access
6 Citations
2,781 Views
14 Pages

Alternative Tobacco Product Use in Critically Ill Patients

  • Tom Liu,
  • Thomas J. Deiss,
  • Matthew W. Lippi,
  • Alejandra Jauregui,
  • Kathryn Vessel,
  • Serena Ke,
  • Annika Belzer,
  • Hanjing Zhuo,
  • Kirsten N. Kangelaris and
  • Antonio D. Gomez
  • + 3 authors

Background: Alternative tobacco product (ATP) use has bee linked to critical illness, however, few studies have examined the use of these substances in critically ill populations. We sought to examine ATP use within critically ill patients and to def...

  • Article
  • Open Access
609 Views
23 Pages

Clinical Implementation of Sustainable Functional Foods and Nutraceuticals in Metabolic Health: A Feasibility Study

  • Francesca Scionti,
  • Samantha Maurotti,
  • Elisa Mazza,
  • Angela Mirarchi,
  • Raffaella Russo,
  • Paola Doria,
  • Rosario Mare,
  • Giuseppe Marafioti,
  • Yvelise Ferro and
  • Tiziana Montalcini
  • + 1 author

10 December 2025

Background: Diet quality significantly influences metabolic health, obesity, and non-communicable disease risk. Functional foods and nutraceuticals, rich in bioactive compounds, may enhance health outcomes beyond basic nutrition, particularly when co...

  • Article
  • Open Access
33 Citations
5,940 Views
22 Pages

The Influence of Selected Food Safety Practices of Consumers on Food Waste Due to Its Spoilage

  • Marzena Tomaszewska,
  • Beata Bilska and
  • Danuta Kołożyn-Krajewska

Food waste in households is a consequence of the accumulation of improper practices employed by consumers when dealing with food. The survey estimated the impact of practices of Polish respondents, in the context of selected food safety and hygiene i...

  • Article
  • Open Access
7 Citations
6,493 Views
13 Pages

A Functional Food Mixture “Protector” Reinforces the Protective Immune Parameters against Viral Flu Infection in Mice

  • Kenza A. Mansoor,
  • Fadi Qadan,
  • Mathias Schmidt,
  • Nidal A. Qinna,
  • Mujtaba Badr and
  • Khalid Z. Matalka

8 June 2018

Background: Viral influenza infection causes serious health issues especially when an outbreak occurs. Although influenza virus vaccines are available and each year manufactures modify the vaccine depending on the expected mutated strain, it is still...

  • Article
  • Open Access
28 Citations
12,508 Views
27 Pages

Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial

  • Kirsten M. Wright,
  • Melissa Bollen,
  • Jason David,
  • Alex B. Speers,
  • Mikah S. Brandes,
  • Nora E. Gray,
  • Armando Alcázar Magaña,
  • Christine McClure,
  • Jan F. Stevens and
  • Claudia S. Maier
  • + 2 authors

23 January 2022

Centella asiatica is reputed in Eastern medicine to improve cognitive function in humans. Preclinical studies have demonstrated that aqueous extracts of C. asiatica improve cognition in mouse models of aging and Alzheimer’s disease (AD) through...

  • Article
  • Open Access
4 Citations
1,984 Views
15 Pages

A Phase 1/2 Randomized Study to Evaluate the Safety, Tolerability, and Immunogenicity of Nucleoside-Modified Messenger RNA Influenza Vaccines in Healthy Adults

  • Angela Branche,
  • Mark J. Mulligan,
  • Alok Maniar,
  • Orlando Puente,
  • Islamiat Oladipupo,
  • Graham Crowther,
  • Agnieszka M. Zareba,
  • Zhuobiao Yi,
  • Ingrid Scully and
  • Emily Gomme
  • + 6 authors

3 April 2025

Background/Objectives: Circulating influenza strains antigenically differing from vaccine antigens increase disease burden by decreasing vaccine efficacy. Nucleoside-modified mRNA (modRNA) influenza vaccines may facilitate rapid production allowing l...

  • Review
  • Open Access
1,872 Views
24 Pages

State of the Art on Vaccine Development Against Dengue Infection: Scoping Review of the Literature

  • Davide Marangoni,
  • Anna Barbiero,
  • Michele Spinicci,
  • Alessandro Bartoloni,
  • Andrea Rossanese,
  • Paolo Bonanni and
  • Lorenzo Zammarchi

17 September 2025

Background: Dengue virus infection is a significant challenge for global health, with 100 million symptomatic cases, 2.3 million DALYs and 20,000 deaths annually. Dengue vaccines must provide long-lasting immunity against all four virus serotypes, es...

  • Article
  • Open Access
14 Citations
6,799 Views
28 Pages

Characterization of Longitudinal Testosterone, Cortisol, and Musth in Male Asian Elephants (Elephas maximus), Effects of Aging, and Adrenal Responses to Social Changes and Health Events

  • Sharon S. Glaeser,
  • Katie L. Edwards,
  • Stephen Paris,
  • Candace Scarlata,
  • Bob Lee,
  • Nadja Wielebnowski,
  • Shawn Finnell,
  • Chaleamchat Somgird and
  • Janine L. Brown

23 May 2022

The conservation of endangered species and sustainability of managed populations requires considerations to ensure the health and welfare of individuals. Male elephants experience a biological phenomenon called “musth”, which is character...

  • Review
  • Open Access
4 Citations
9,420 Views
32 Pages

Asthma is a chronic and multifaceted respiratory condition that affects over 300 million individuals across the globe. It is characterized by persistent inflammation of the airways, which leads to episodes of wheezing, breathlessness, chest tightness...

  • Article
  • Open Access
12 Citations
3,422 Views
14 Pages

Acceptance and Risk Perception of COVID-19 Vaccination among Pregnant and Non Pregnant Women in Sub-Saharan Africa: A Cross-Sectional Matched-Sample Study

  • Onyekachukwu M. Amiebenomo,
  • Uchechukwu L. Osuagwu,
  • Esther Awazzi Envuladu,
  • Chundung Asabe Miner,
  • Khathutshelo P. Mashige,
  • Godwin Ovenseri-Ogbomo,
  • Emmanuel Kwasi Abu,
  • Chikasirimobi Goodhope Timothy,
  • Bernadine N. Ekpenyong and
  • Raymond Langsi
  • + 5 authors

20 February 2023

This study aims to evaluate the acceptance and risk perception of pregnant and non pregnant women towards COVID-19 vaccines using a cross-sectional matched-sample study approach. A web-based questionnaire with closed- and open-ended questions was adm...

  • Article
  • Open Access
883 Views
14 Pages

Dual Protective Effects of Postbiotics and Cichorium intybus L. Mixture in the Sarcopenic and Inflammatory Models

  • Harang Park,
  • Jinsu Choi,
  • Eunwoo Jeong,
  • Hye-Yeong Song,
  • Juyeong Moon,
  • Min-ah Kim,
  • Chunghyeon Lee,
  • Junsoo Park,
  • Jong Kwang Hong and
  • Tack-Joong Kim

Background/Objectives: Recently, concerns about age-related conditions, such as sarcopenia and chronic inflammation, have increased owing to the global acceleration of population aging. Notably, these conditions are interrelated and further exacerbat...

  • Article
  • Open Access
4 Citations
8,345 Views
19 Pages

Augmenting Cognitive Function in the Elderly with Mild Cognitive Impairment Using Probiotic Lacticaseibacillus rhamnosus CBT-LR5: A 12-Week Randomized, Double-Blind, Parallel-Group Non-Comparative Study

  • Su-Jin Jung,
  • Kyohee Cho,
  • Eun-Soo Jung,
  • Dooheon Son,
  • Jong-Seon Byun,
  • Song-In Kim,
  • Soo-Wan Chae,
  • Jong-Chul Yang,
  • Seung-Ok Lee and
  • Sanghyun Lim

14 February 2025

Background: Probiotics have been shown to enhance cognitive function in individuals with mild cognitive impairment (MCI), but their efficacy varies, depending on the strain and dosage. Objectives: Clinical investigations are crucial to confirm their...