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  • Article
  • Open Access
4 Citations
3,687 Views
12 Pages

Swept-Source OCT Mid-Peripheral Retinal Irregularity in Retinal Detachment and Posterior Vitreous Detachment Eyes

  • Stewart R. Lake,
  • Murk J. Bottema,
  • Tyra Lange,
  • Keryn A. Williams and
  • Karen J. Reynolds

Irregularities in retinal shape have been shown to correlate with axial length, a major risk factor for retinal detachment. To further investigate this association, a comparison was performed of the swept-source optical coherence tomography (SS OCT)...

(This article belongs to the Special Issue Biomedical Applications of Optical Coherence Tomography)
  • Article
  • Open Access
2 Citations
2,602 Views
12 Pages

Posterior Vitreous Detachment in Healthy Versus AMD Eyes Assessed by Widefield Optical Coherence Tomography

  • Maciej Gawęcki,
  • Krzysztof Kiciński,
  • Andrzej Grzybowski and
  • Sławomir Teper

Introduction: This study aimed to determine the frequency of posterior vitreous detachment (PVD) in dry and wet age-related macular degeneration (AMD) patients compared with healthy eyes via ultrawide field optical coherence tomography (UWF–OCT...

(This article belongs to the Special Issue Latest Advances in Ophthalmic Imaging)
  • Article
  • Open Access
1 Citations
922 Views
10 Pages

Clinical Outcomes of Full-Thickness Macular Holes with Epiretinal Proliferation Without Posterior Vitreous Detachment

  • Kota Kakehashi,
  • Reio Sekine,
  • Tatsuya Jujo,
  • Naoto Uchiyama and ,
  • Akiko Endo,
  • Naoto Tokuda and
  • Yasushi Kitaoka
  • + 2 authors+ 0 author

4 November 2025

Background and Objective: To elucidate the clinical characteristics of full-thickness macular holes (FTMHs) with epiretinal proliferation (EP) without posterior vitreous detachment (PVD). Material and Methods: A retrospective and exploratory study re...

(This article belongs to the Special Issue Modern Diagnostics and Therapy for Vitreoretinal Diseases)
  • Article
  • Open Access
1 Citations
2,600 Views
13 Pages

4 December 2025

Background/Objectives: Posterior vitreous detachment (PVD) is an age-related physiological process, yet the clinical and biometric factors influencing its progression remain incompletely characterized in adults undergoing routine ophthalmic evaluatio...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
577 Views
13 Pages

20 May 2026

Background/Objectives: Posterior vitreous detachment (PVD), which is closely related to epiretinal membrane (ERM) formation, can affect macular microstructure and function through persistent tractional forces. The aim of this study was to evaluate wh...

(This article belongs to the Special Issue New Sights in Retinal Diseases Therapeutics: Innovation and Clinical Practice)
  • Article
  • Open Access
765 Views
11 Pages

Mechanisms of Gas-Induced Posterior Vitreous Detachment: A Look Behind the Bubble Using Optical Coherence Tomography in Prone Position

  • Julian Elias Klaas,
  • Jakob Siedlecki,
  • Benedikt Schworm,
  • Nikolaus Feucht and ,
  • Mathias Maier and
  • Siegfried G. Priglinger
  • + 1 author+ 0 author

9 February 2026

Objectives: We aimed to visualize the interaction of intravitreal gas with the adjacent vitreomacular interface by using prone position (PP) SD-OCT and suggest possible mechanisms of action behind gas-induced posterior vitreous detachment (PVD) in pn...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
4 Citations
4,274 Views
11 Pages

18 October 2022

Retinal detachment (RD) is one of the most common, sight-threatening ocular conditions requiring emergency intervention. Posterior vitreous detachment (PVD) occurs in the majority of an aging population whereby the vitreous body separates from the re...

(This article belongs to the Special Issue Genetics in Stickler Syndrome)
  • Article
  • Open Access
1 Citations
2,255 Views
8 Pages

Role of Vitreous Detachment in Epiretinal Membrane Peeling: A Multimodal Imaging and Microperimetry Study

  • Federica Serino,
  • Fabrizio Gaetano Saverio Franco,
  • Daniela Bacherini,
  • Marco Lupidi and ,
  • Stefano Gallio,
  • Claudio Esposito,
  • Gianni Virgili,
  • Cesare Mariotti and
  • Fabrizio Giansanti
  • + 4 authors+ 0 author

18 June 2024

Background: To investigate anatomical and functional changes of the macula caused by epiretinal membrane (ERM) peeling procedures in patients with or without posterior vitreous detachment (PVD). Methods: This is a multicentric prospective observation...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
1,341 Views
17 Pages

Ultrasound-Enhanced Assessment of Vitreous Status in Exudative AMD: Associations with Neovascular Phenotypes, Treatment Burden, and Functional Outcomes

  • Cristina Rodriguez-Vidal,
  • Lucía Galletero Pandelo,
  • Nerea Martínez-Alday,
  • Manuel Bande and
  • María José Blanco Teijeiro

25 December 2025

Background/Objectives: The influence of the vitreoretinal interface on neovascular age-related macular degeneration (nAMD) remains poorly characterized. Most previous studies relied solely on macular optical coherence tomography (OCT), which provides...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
9 Citations
4,541 Views
14 Pages

Risk Factors for Recurrent Vitreous Hemorrhage in Type 2 Diabetes Mellitus Patients after Posterior Vitrectomy

  • Marc Baget-Bernaldiz,
  • Pedro Romero-Aroca,
  • Alejandra Mira-Puerto,
  • Angel Bautista-Perez and ,
  • Immaculada Roca-Borrut,
  • Montse Vizcarro,
  • Raul Navarro-Gil and
  • Monica Llagostera-Serra
  • + 3 authors+ 0 author

20 April 2023

(Background) The aim of this study was to determine the factors related to recurrent vitreous hemorrhage (RVH) in a sample of proliferative diabetic retinopathy (PDR) patients. (Methods) This was a retrospective, review-based study. We studied 183 ey...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
2 Citations
2,158 Views
10 Pages

Comparing New Smartphone-Connected Handheld Ultrasound Device vs. Traditional Ultrasound in Vitreo-Retinal Disease Diagnosis

  • Giovanni Rubegni,
  • Marco Zeppieri,
  • Andrea Russo,
  • Niccolò Castellino and ,
  • Mario Fruschelli,
  • Theodora Hadjistilianou,
  • Linda Tognetti,
  • Matteo Orione,
  • Luca Lanzafame and
  • Teresio Avitabile
  • + 8 authors+ 3 authors

5 September 2024

(1) Background: Ocular emergencies account for 1.5–3% of emergency department (ED) visits and require urgent diagnosis to prevent serious complications. Ultrasonography is a crucial, non-invasive diagnostic tool for these conditions but traditi...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Case Report
  • Open Access
2,715 Views
10 Pages

Posterior Dislocation of Descemet Stripping Automated Endothelial Keratoplasty—A Case Report and Review

  • Valentino de Ruvo,
  • Alfonso Strianese,
  • Lily Chacra,
  • Luca Rossetti and ,
  • Fabio Patelli and
  • Paolo Fogagnolo
  • + 1 author+ 0 author

In this study, we describe a case of graft dislocation into the vitreous cavity after Descemet stripping automated endothelial keratoplasty (DSAEK), and review the risk factors and complications of posterior dislocation. A 70-year-old female with dis...

  • Case Report
  • Open Access
739 Views
10 Pages

Background and Clinical Significance: To describe two cases within the spectrum of non-myopic foveomacular retinoschisis, including stellate non-hereditary idiopathic foveomacular retinoschisis (SNIFR) and central anomalous retinoschisis with mid-per...

(This article belongs to the Special Issue Diagnosis and Management of Ophthalmic Disorders)
  • Article
  • Open Access
18 Citations
13,631 Views
15 Pages

20 September 2022

Purpose: To describe the appearance of vitreous opacities using dynamic ultra-widefield infrared confocal scanning laser ophthalmoscopy (IRcSLO). Design: Retrospective case series. Methods: Eyes of patients complaining of myodesopsia were analyzed us...

(This article belongs to the Special Issue Recent Advances in Vitreoretinal Surgery)
  • Article
  • Open Access
6 Citations
2,104 Views
11 Pages

Evaluation of Ocular and Systemic Oxidative Stress Markers in Patients with Diabetic Retinopathy

  • Ana Karen López-Contreras,
  • Diana Esperanza Arévalo-Simental,
  • Fermín Paúl Pacheco-Moisés,
  • María Guadalupe Martínez-Ruíz and ,
  • Cecilia Olvera-Montaño,
  • Ricardo Raúl Robles-Rivera,
  • Sonia Sifuentes-Franco,
  • Tannia Isabel Campos-Bayardo,
  • Selene Guadalupe Huerta-Olvera and
  • Adolfo Daniel Rodríguez-Carrizalez
  • + 5 authors+ 0 author

2 December 2024

Proliferative diabetic retinopathy (PDR) is the most severe complication of chronic hyperglycaemi stimulates oxidative stress that changes the retinal basement membrane function and provokes neovascularization, macular edema and retinal detachment. B...

(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 2nd Edition)
  • Review
  • Open Access
15 Citations
6,133 Views
16 Pages

Wide-field (WF) retinal imaging is becoming a standard diagnostic tool for diseases involving the peripheral retina. Technological progress elicited the advent of wide-field optical coherence tomography (WF-OCT) and WF-OCT angiography (WF-OCTA) exami...

(This article belongs to the Special Issue State of the Art in Retinal Optical Coherence Tomography Images)
  • Communication
  • Open Access
5 Citations
8,919 Views
8 Pages

To investigate the temporary tamponade effects of an ophthalmic viscosurgical device (OVD) for experimental retinal tears, we performed vitrectomy in four rabbit eyes and created a posterior vitreous detachment and artificial retinal tear to produce...

  • Brief Report
  • Open Access
5 Citations
2,447 Views
8 Pages

Vitreal Concentrations of Vascular Endothelial Growth Factor in Patients with Rhegmatogenous Retinal Detachment

  • Hossein Hasanpour,
  • Maria Cristina Kenney,
  • Baruch D. Kuppermann,
  • Mohammad Riazi Esfahani and ,
  • Mozhgan Rezaei Kanavi,
  • Mithalesh Kumar Singh and
  • Masoud Soheilian
  • + 2 authors+ 0 author

5 February 2023

The purpose of this study is to evaluate the concentration of vascular endothelial growth factor (VEGF) in the vitreous humor of patients with primary rhegmatogenous retinal detachment (RRD). This is a prospective case control study. Eighteen patient...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
6 Citations
3,101 Views
9 Pages

Effect of the COVID-19 Pandemic on Surgical Outcomes for Rhegmatogenous Retinal Detachments

  • Masaharu Mizuno,
  • Kosuke Nakajima,
  • Aya Takahashi,
  • Tomoka Ishida and ,
  • Kazunari Hirota,
  • Takashi Koto,
  • Akito Hirakata and
  • Makoto Inoue
  • + 3 authors+ 0 author

15 February 2023

We reviewed the medical records of 438 eyes in 431 patients who had undergone surgeries for rhegmatogenous retinal detachments (RRD) or proliferative vitreoretinopathy (PVR ≥ Grade C) to determine whether the COVID-19 pandemic had affected outcome...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
12 Citations
2,959 Views
7 Pages

Open Globe Injury (OGI) with a Presence of an Intraocular Foreign Body (IOFB)—Epidemiology, Management, and Risk Factors in Long Term Follow-Up

  • Michał Jabłoński,
  • Mateusz Winiarczyk,
  • Katarzyna Biela,
  • Paweł Bieliński and ,
  • Monika Jasielska,
  • Joanna Batalia and
  • Jerzy Mackiewicz
  • + 2 authors+ 0 author

26 December 2022

The purpose of the study was to evaluate visual outcomes and consider management strategies in the eyes with an intraocular foreign body (IOFB). In a single-center, retrospective case-control study, 36 eyes of 36 patients who suffered from open globe...

(This article belongs to the Special Issue Advances in Vitreoretinal Interventions for Eye Diseases)
  • Article
  • Open Access
6 Citations
2,937 Views
10 Pages

A Modified Single-Armed Suture Technique for Traumatic Cyclodialysis Cleft with Vitreoretinal Injury

  • Xueyong Zhang,
  • Nan Wang,
  • Guoli Zheng,
  • Die Liu and ,
  • Quyan Zhang,
  • Wenbo Lei,
  • Xiaobo Xia and
  • Siqi Xiong
  • + 3 authors+ 0 author

25 June 2023

Our aim was to assess the therapeutic efficacy of a modified single-arm suture technique on traumatic cyclodialysis cleft with vitreoretinal injury. The procedure involved fixing a detached ciliary body using a single-armed 10-0 polypropylene suture...

(This article belongs to the Special Issue State-of-the-Art Research on Vitreoretinal Disorders)
  • Article
  • Open Access
1 Citations
2,593 Views
10 Pages

Outcomes of Vitrectomy for Macular Pathologies Associated with Idiopathic Vasoproliferative Retinal Tumor

  • Masatoshi Shinozaki,
  • Hiromi Ohara,
  • Tomohiko Torikai,
  • Takashi Koto and
  • Makoto Inoue

3 September 2025

Background/Objectives: A vasoproliferative retinal tumor (VPT) is a rare, benign, vascular tumor that is found in the peripheral retina. We retrospectively investigated the clinical characteristics and the outcomes of pars plana vitrectomy (PPV) on i...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
1 Citations
1,188 Views
12 Pages

Spatiotemporal Mapping of Biomechanical Stress Predicts Region-Specific Retinal Injury in a Murine Model of Blunt Ocular Trauma

  • Jianing Wang,
  • Ji An Lee,
  • Yingnan Zhai,
  • Kourosh Shahraki and ,
  • Pengfei Dong,
  • Donny W. Suh and
  • Linxia Gu
  • + 2 authors+ 0 author

Retinal detachments following blunt ocular trauma are challenging to predict due to the complex and transient biomechanical responses of the globe. This study combines an in vitro weight-drop experiment and finite element analysis (FEA) to evaluate t...

(This article belongs to the Special Issue Multiscale Mechanics of Biomaterials)
  • Article
  • Open Access
20 Citations
3,785 Views
9 Pages

Double-Needle Yamane Technique Using Flanged Haptics in Ocular Trauma—A Retrospective Survey of Visual Outcomes and Safety

  • Katarzyna Nowomiejska,
  • Dariusz Haszcz,
  • Maksymilian Onyszkiewicz,
  • Tomasz Choragiewicz and ,
  • Aleksandra Czarnek-Chudzik,
  • Agata Szpringer-Wabicz,
  • Katarzyna Baltaziak,
  • Agnieszka Brzozowska,
  • Mario Damiano Toro and
  • Robert Rejdak
  • + 5 authors+ 0 author

9 June 2021

To evaluate visual outcomes and safety of the double-needle technique using flanged haptics (Yamane technique) in patients with aphakia caused by ocular trauma at a trauma referral center. Retrospective: Consecutive interventional case series of 30 p...

(This article belongs to the Special Issue Updates in Ocular Surgery)
  • Article
  • Open Access
4 Citations
1,811 Views
10 Pages

Needle-Guided Scleral Fixation: A New Single-Suture Approach

  • Laura De Luca,
  • Giovanni William Oliverio,
  • Maura Mancini,
  • Rino Frisina and ,
  • Feliciana Menna,
  • Stefano Lupo,
  • Pierluigi Grenga,
  • Cosimo Mazzotta,
  • Pasquale Aragona and
  • Alessandro Meduri
  • + 5 authors+ 0 author

22 December 2025

Background: Scleral fixation of intraocular lenses (IOLs) is a valuable option in cases of aphakia or inadequate capsular support, yet conventional sutured and sutureless approaches can pose technical challenges and complication risks. The needle-gui...

(This article belongs to the Special Issue New Insights in Ophthalmic Surgery)
  • Perspective
  • Open Access
3 Citations
3,279 Views
11 Pages

Introduction: Epiretinal membrane (ERM) is a relatively common condition affecting the macula. When symptoms become apparent and compromise a patient’s quality of vision, the only therapeutic approach available today is surgery with a vitrectom...

(This article belongs to the Section Molecular and Translational Medicine)
  • Article
  • Open Access
7 Citations
2,734 Views
9 Pages

Multimodal Evaluation and Management of Wagner Syndrome—Three Patients from an Affected Family

  • Tomasz Szeligowski,
  • Jasmina Cehajic-Kapetanovic,
  • Shabnam Raji,
  • Ravi Purohit and ,
  • Hoda Amin,
  • Chetan K. Patel and
  • Kanmin Xue
  • + 2 authors+ 0 author

8 September 2024

Wagner syndrome is a rare autosomal dominant vitreoretinopathy caused by mutations in chondroitin sulphate proteoglycan 2 (CSPG2)/Versican (VCAN). Here, we present a retrospective case series of a family pedigree with genetically confirmed Wagner syn...

(This article belongs to the Section Human Genomics and Genetic Diseases)
  • Article
  • Open Access
3 Citations
3,845 Views
9 Pages

Ophthalmic Manifestations among HIV Patients at the Main Tertiary Hospital in Freetown, Sierra Leone: A Cross-Sectional Study

  • Jalikatu Mustapha,
  • Enanga Sonia Namanga,
  • Baimba Idriss,
  • Daniel Sesay and ,
  • Darlinda F. Jiba,
  • James B. W. Russell,
  • Mathew J. Vandy,
  • Gibrilla F. Deen,
  • George A. Yendewa and
  • Sulaiman Lakoh
  • + 5 authors+ 0 author

Ophthalmic diseases are common among people living with HIV (PLHIV) in developing countries. However, there are currently no published studies on ophthalmic complications among PLHIV in Sierra Leone. We conducted a cross-sectional study of PLHIV pres...

  • Article
  • Open Access
10 Citations
5,261 Views
11 Pages

Clinical Manifestations and Outcomes of Tubercular Uveitis in Taiwan—A Ten-Year Multicenter Retrospective Study

  • Chun-Ju Lin,
  • Ning-Yi Hsia,
  • De-Kuang Hwang,
  • Yih-Shiou Hwang and ,
  • Yo-Chen Chang,
  • Yueh-Chang Lee,
  • Yung-Ray Hsu,
  • Po-Ting Yeh,
  • Chang-Ping Lin and
  • Ming-Ling Tsai
  • + 8 authors+ 3 authors

3 March 2022

Background andObjectives: This 10-year multicenter retrospective study reviewed the clinical manifestations, diagnostic tests, and treatment modalities of tubercular uveitis (TBU), including direct infection and indirect immune-mediated hypersensitiv...

(This article belongs to the Special Issue Diagnosis and Treatment of Uveitis)
  • Article
  • Open Access
7 Citations
3,794 Views
18 Pages

Lipid-DNA Nanoparticles as Drug-Delivery Vehicles for the Treatment of Retinal Diseases

  • Sven Schnichels,
  • David Simmang,
  • Marina Löscher,
  • Andreas Herrmann and ,
  • Jan Willem de Vries,
  • Martin S. Spitzer and
  • José Hurst
  • + 2 authors+ 0 author

Retinal eye diseases are the leading cause of blindness in the Western world. Up to date, the only efficient treatment for many retinal diseases consists of invasive intravitreal injections of highly concentrated drugs. Despite the fact that these in...

(This article belongs to the Special Issue Recent Advances in Ocular Drug Delivery)
  • Article
  • Open Access
2 Citations
3,498 Views
14 Pages

Spontaneously Opening and Closing Macular Holes with Lamellar Hole Epiretinal Proliferation: A Longitudinal Optical Coherence Tomography Analysis

  • Omar Moussa,
  • Jedrzej Golebka,
  • Gabriel Gomide,
  • Dvir Koenigstein and ,
  • Hueyjong Shih and
  • Royce W. S. Chen
  • + 1 author+ 0 author

Background/Objectives: Spontaneous macular hole closure is a rare phenomenon, with lamellar hole epiretinal proliferation (LHEP) frequently implicated as a potential mechanism. This study aims to analyze the presence of LHEP in patients with full-thi...

(This article belongs to the Special Issue Optical Coherence Tomography in Diagnosis of Ophthalmology Disease)
  • Review
  • Open Access
3 Citations
3,077 Views
37 Pages

The Impact of Vitreoretinal Surgery in Patients with Uveitis: Current Strategies and Emerging Perspectives

  • Dimitrios Kalogeropoulos,
  • Sofia Androudi,
  • Marta Latasiewicz,
  • Youssef Helmy and ,
  • Ambreen Kalhoro Tunio,
  • Markus Groppe,
  • Mandeep Bindra,
  • Mohamed Elnaggar,
  • Georgios Vartholomatos and
  • Chris Kalogeropoulos
  • + 6 authors+ 1 author

Uveitis constitutes a heterogeneous group of intraocular inflammatory pathologies, including both infectious and non-infectious aetiologies, often leading to substantial morbidity and permanent loss of vision in up to 20% of the affected cases. Visua...

(This article belongs to the Special Issue Advanced Diagnostic Approaches in Uveitis and Inflammatory Vitreoretinal Diseases)
  • Article
  • Open Access
9 Citations
3,264 Views
10 Pages

Long-Term Results of Adjunct Autologous Platelet-Rich Plasma in Lamellar Macular Hole Surgery Showing Lasting Restoration of Foveal Anatomy

  • Felix Hagenau,
  • Elisa V. Osterode,
  • Julian E. Klaas,
  • Denise Vogt and ,
  • Leonie F. Keidel,
  • Benedikt Schworm,
  • Jakob Siedlecki,
  • Wolfgang J. Mayer,
  • Thomas C. Kreutzer and
  • Siegfried G. Priglinger
  • + 5 authors+ 0 author

27 February 2023

The aim of this study was to evaluate the long-time results of highly concentrated autologous platelet-rich plasma (PRP) used as an adjunct in lamellar macular hole (LMH) surgery. Nineteen eyes of nineteen patients with progressive LMH were enrolled...

(This article belongs to the Special Issue Advances in Platelet Biology and Functions)
  • Case Report
  • Open Access
192 Views
8 Pages

Spontaneous Resolution of a Unilateral Epiretinal Membrane in Bilateral Peripheral Retinal Vasculopathy: A Case Report

  • Alessandro Avitabile,
  • Maria Ludovica Ruggeri,
  • Alberto Quarta,
  • Corina Valentina de Santis Ciacci and
  • Vincenza Maria Elena Bonfiglio

16 October 2026

Background and Clinical Significance: Epiretinal membranes (ERMs) are uncommon in young patients, and spontaneous anatomical resolution is rare. We report spontaneous disappearance of a unilateral ERM after marked worsening in an 18-year-old woman wi...

(This article belongs to the Section Ophthalmology)
  • Systematic Review
  • Open Access
4 Citations
2,017 Views
28 Pages

OCTA Biomarkers Underlying Structure–Function Correlations in Idiopathic Epiretinal Membrane: A Systematic Review

  • Anca Mădălina Sere,
  • George Adrian Muntean,
  • Andreea Petra Cristea and
  • Simona Delia Nicoară

15 October 2025

Background: Idiopathic epiretinal membrane (iERM) is a common retinal pathology in elderly patients, thought to originate primarily from an anomalous process of posterior vitreous detachment. The standard treatment is pars plana vitrectomy (PPV) with...

(This article belongs to the Special Issue Optical Coherence Tomography in Diagnosis of Ophthalmology Disease)