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18 Results Found

  • Article
  • Open Access
17 Citations
4,042 Views
19 Pages

Spinach Methanolic Extract Attenuates the Retinal Degeneration in Diabetic Rats

  • Rocio Bautista-Pérez,
  • Agustina Cano-Martínez,
  • Elisa Gutiérrez-Velázquez,
  • Martín Martínez-Rosas,
  • Rosa M. Pérez-Gutiérrez,
  • Francisco Jiménez-Gómez and
  • Javier Flores-Estrada

It has been suggested that spinach methanolic extract (SME) inhibits the formation of advanced glycation end products (AGEs), which are increased during diabetes progression, so it is important to know if SME has beneficial effects in the diabetic re...

  • Article
  • Open Access
19 Citations
4,368 Views
22 Pages

Glyoxal (GO) and methylglyoxal (MGO) are highly reactive species formed in carbohydrate metabolism. Nε-Carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL) are considered to be the advanced glycation end-products (AGEs) of L-lysi...

  • Article
  • Open Access
2 Citations
1,513 Views
20 Pages

Spinach Extract Reduces Kidney Damage in Diabetic Rats by Impairing the AGEs/RAGE Axis

  • Javier Flores-Estrada,
  • Agustina Cano-Martínez,
  • Luz Ibarra-Lara,
  • Adriana Jiménez,
  • Carmen Palacios-Reyes,
  • Luis J. Pinto García,
  • María G. Ortiz-López,
  • Olga Nelly Rodríguez-Peña and
  • Luis Barbo Hernández-Portilla

The interaction between advanced glycation end products (AGEs) and their RAGE receptor (AGEs/RAGE axis) triggers several signaling pathways that lead to the development of diabetic nephropathy (DN). One of the most studied AGEs is Nε-(1-Carbo...

  • Article
  • Open Access
25 Citations
16,080 Views
11 Pages

12 June 2020

Dietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would ele...

  • Article
  • Open Access
7 Citations
2,375 Views
13 Pages

10 October 2023

Advanced glycation end products (AGEs) and heterocyclic amines (HAs) are two kinds of important harmful products formed simultaneously during the thermal processing of proteinaceous food. In this paper, the effect of roasting conditions on the format...

  • Article
  • Open Access
1 Citations
1,897 Views
13 Pages

10 October 2025

Background/Objectives: The prebiotic effect of resistant potato starch (RPS) has been demonstrated, but the antioxidant properties associated with this ingredient have not been explored. Methods: We performed post hoc analysis of serum metabolomic da...

  • Article
  • Open Access
20 Citations
6,209 Views
17 Pages

Advanced glycation end products (AGE), the most known aging biomarker, may cause “inflamm-aging” (i.e., chronic low-grade inflammation that develops with aging) in both aged and diabetes groups. However, the molecular bases of inflamm-agi...

  • Article
  • Open Access
1 Citations
2,259 Views
20 Pages

19 June 2025

This study systematically investigated the evolution of color values and the reaction kinetics of the Maillard reaction in membrane-clarified sugarcane juice during the vacuum evaporation process, providing a theoretical basis for pigment regulation...

  • Article
  • Open Access
21 Citations
6,441 Views
13 Pages

23 December 2017

Positively-charged ε-poly(l-lysine) (ε-PL) and negatively-charged carboxymethyl cellulose (CMC) were alternately deposited on a cellulose paper surface by the layer-by-layer (LBL) assembly technique. The formation of ε-PL/CMC multilayers was confirme...

  • Article
  • Open Access
1 Citations
950 Views
20 Pages

5 November 2025

Polianthes tuberosa L. (PT) flower extracts exhibit considerable bioactivities, yet their application is often constrained by limited bioavailability and efficacy. In this study, fermentation of PT (FPT) using Rhodosporidium toruloides significantly...

  • Article
  • Open Access
17 Citations
6,222 Views
13 Pages

22 December 2017

Glucose autoxidation has been proposed as a key reaction associated with deleterious effects induced by hyperglycemia in the eye lens. Little is known about chromophores generated during glucose autoxidation. In this study, we analyzed the effect of...

  • Article
  • Open Access
12 Citations
3,437 Views
17 Pages

Antiglycating Effect of Phenolics from the Chilean Currant Ribes cucullatum under Thermal Treatment

  • Felipe Ávila,
  • Natalia Ravello,
  • Camila Manriquez,
  • Felipe Jiménez-Aspee,
  • Guillermo Schmeda-Hirschmann and
  • Cristina Theoduloz

Numerous dietary polyphenols possess antiglicating activity, but the effects of thermal treatment on this activity are mostly unknown. The effect of thermal treatment in the antiglycating activity of polyphenolic enriched extracts (PEEs) from Ribes c...

  • Feature Paper
  • Article
  • Open Access
29 Citations
5,458 Views
18 Pages

Differential Effects of Dry vs. Wet Heating of β-Lactoglobulin on Formation of sRAGE Binding Ligands and sIgE Epitope Recognition

  • Hannah E. Zenker,
  • Arifa Ewaz,
  • Ying Deng,
  • Huub F. J. Savelkoul,
  • R.J. Joost van Neerven,
  • Nicolette W. De Jong,
  • Harry J. Wichers,
  • Kasper A. Hettinga and
  • Malgorzata Teodorowicz

25 June 2019

The effect of glycation and aggregation of thermally processed β-lactoglobulin (BLG) on binding to sRAGE and specific immunoglobulin E (sIgE) from cow milk allergic (CMA) patients were investigated. BLG was heated under dry conditions (water act...

  • Article
  • Open Access
18 Citations
5,794 Views
19 Pages

Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks

  • Yixiao Shen,
  • Jing Han,
  • Xiaoyan Zheng,
  • Binling Ai,
  • Yang Yang,
  • Dao Xiao,
  • Lili Zheng and
  • Zhanwu Sheng

26 March 2020

Advanced glycation end products (AGEs) generated from glycation can cause inflammation-related diseases such as diabetes and cancer. The bioactive compounds of rosemary extract (RE) were extracted and incubated with sugar-protein rich food and breast...

  • Article
  • Open Access
1,112 Views
16 Pages

Serum Levels of Nε-(Carboxymethyl)-Lysine in Chronic Kidney Disease and Type 2 Diabetes Mellitus

  • Rositsa Tsekovska,
  • Evan Gatev,
  • Roumyana Mironova,
  • Simona Kerezieva,
  • Siyana Ilieva,
  • Teodora Ilieva,
  • Bilyana Vasileva,
  • Toshimitsu Niwa,
  • Daniela Popova and
  • Vasil Vasilev

Background: Nε-(carboxymethyl)-lysine (CML) is formed in the human body by non-enzymatically driven reactions including glycation, oxidation, and lipoxidation. CML is a ubiquitous product of normal physiology, but its levels are increased und...

  • Article
  • Open Access
4 Citations
3,487 Views
15 Pages

14 May 2022

Spices are known to have various physiological functions. We focused on the anti-glycation effects of spices, researched anti-glycation active ingredients in coriander (Coriandrum sativum L.) and fennel (Foeniculum vulgare) seeds, and conducted exper...

  • Article
  • Open Access
7 Citations
3,333 Views
15 Pages

Construction of Microbial Consortium to Enhance Cellulose Degradation in Corn Straw during Composting

  • Jie Li,
  • Juan Li,
  • Ruopeng Yang,
  • Ping Yang,
  • Hongbo Fu,
  • Yongchao Yang and
  • Chaowei Liu

16 September 2024

The improper treatment of crop straw not only leads to resource wastage but also adversely impacts the ecological environment. However, the application of microorganisms can accelerate the decomposition of crop straw and improve its utilization. In t...

  • Article
  • Open Access
6 Citations
4,783 Views
16 Pages

Dietary and Plasma Carboxymethyl Lysine and Tumor Necrosis Factor-α as Mediators of Body Mass Index and Waist Circumference among Women in Indonesia

  • Patricia Budihartanti Liman,
  • Rina Agustina,
  • Ratna Djuwita,
  • Jahja Umar,
  • Inge Permadhi,
  • Helmizar,
  • Adi Hidayat,
  • Edith J.M. Feskens and
  • Murdani Abdullah

14 December 2019

Dietary and plasma carboxymethyl lysine (dCML, pCML) and plasma tumor necrosis factor-α (pTNF-α) may be associated with obesity in affluent society. However, evidence in women from low-middle income countries with predominantly traditiona...