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Open AccessArticle

Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks

by Yixiao Shen 1,2,†, Jing Han 1,3,†, Xiaoyan Zheng 1, Binling Ai 1, Yang Yang 1, Dao Xiao 1, Lili Zheng 1,* and Zhanwu Sheng 1,*
Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570101, China
College of Food Science, Shenyang Agricultural University, Shenyang 110161, China
Gansu Cheezheng Industrial Group Co., Ltd., Gansu 730010, China
Authors to whom correspondence should be addressed.
The authors have contributed equally to this manuscript.
Appl. Sci. 2020, 10(7), 2249;
Received: 19 February 2020 / Revised: 11 March 2020 / Accepted: 18 March 2020 / Published: 26 March 2020
(This article belongs to the Section Food Science and Technology)
Advanced glycation end products (AGEs) generated from glycation can cause inflammation-related diseases such as diabetes and cancer. The bioactive compounds of rosemary extract (RE) were extracted and incubated with sugar-protein rich food and breast cancer cell MCF-7 to investigate its inhibitory effect on glycation and cancer cell proliferation, respectively. The diabetic rat was dosed with RE to investigate its effect on blood glucose, serum malondialdehyde (MDA), cholesterol (CHO), triglycerides (TG), low-density lipoproteins (LDLs), anti-oxidation capacity (T-AOC), superoxide dismutase (SOD) activity, anti-oxidation capacity alkaline phosphatase (ALP), glutamate pyruvate transaminase (GPT), and glutamate oxaloacetate transaminase (GOT). The results show that RE contained seven major phenolics ranging from 17.82 mg/g for rosemarinic acid to 0.01 mg/g for ferulic acid on dry weight basis. It significantly lowered AGEs, carboxymethyl lysine (CML), and protein glycation in a sugar-protein rich intermediate-moisture-food (IMF) model. Furthermore, the survival rates of MCF-7 cells decreased to 6.02 and 2.16% after 96 h of incubation with 1.0 and 2.0 mg/mL of RE, respectively. The blood glucose, MDA, CHO, TG, and LDLs in diabetic rats of RE treatment were decreased. The RE treatment also enhanced the T-AOC and SOD activity. Furthermore, the RE treatment improved liver function through improving ALP, GPT, and GOT activities in diabetic rats. The results provide important information for the nutriaceutical and pharmaceutical application of rosemary extract. View Full-Text
Keywords: rosemary; glycation; cancer; diabetes; phenolics rosemary; glycation; cancer; diabetes; phenolics
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Shen, Y.; Han, J.; Zheng, X.; Ai, B.; Yang, Y.; Xiao, D.; Zheng, L.; Sheng, Z. Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks. Appl. Sci. 2020, 10, 2249.

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